2,6-二氯-3-氯甲基吡啶合成路线 （共 8 条）
反应条件
thionyl chloride; N,N-dimethyl-formamide in dichloromethane T=0 - 25°C; 6 h; Inert atmosphere;
参考文献
BRANDEIS UNIVERSITY; SNIDER, Barry; ZHOU, Quan
Patent: WO2012/78608 A1, 2012 ;
Location in patent: Page/Page column 28-29 ;
反应条件
N-ethyl-N,N-diisopropylamine in hexane; dichloromethane
参考文献
Wyeth
Patent: US6511974 B1, 2003 ;
US 6511974 B1
反应条件
1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C / Inert atmosphere 2: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 6 h / 0 - 25 °C / Inert atmosphere View Scheme
参考文献
BRANDEIS UNIVERSITY; SNIDER, Barry; ZHOU, Quan
Patent: WO2012/78608 A1, 2012 ;
参考文献
Barlow, Michael G.; Sibous, Lakhdar; Tipping, Anthony E.
Tetrahedron Letters, 1992 , vol. 33, # 32 p. 4653 - 4656
反应条件
water 1.) 70 deg C, 4 d, 2.) CH2Cl2, 3 h; Yield given. Multistep reaction;
参考文献
Barlow, Michael G.; Sibous, Lakhdar; Suliman, Nadia N. E.; Tipping, Anthony E.
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 6 p. 519 - 524
反应条件
CuSO4; nitric acid in water
参考文献
Ciba-Geigy Corporation
Patent: US3956340 A1, 1976 ;
反应条件
in ethanol; water
T=80°C; 4 h; Inert atmosphere;
参考文献
Zhou, Quan; Snider, Barry B.
Organic Letters, 2011 , vol. 13, # 3 p. 526 - 529
反应条件
in phosphorus pentoxide
参考文献
Ciba-Geigy Corporation
Patent: US3974166 A1, 1976 ;
