反应条件
1: 1-methyl-1H-imidazole-4-carboxylic acid With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine in tetrahydrofuran; N,N-dimethyl-formamide
T=20°C; 0.333333 h;
2: O,N-dimethyl-hydroxylamine hydrochloride in tetrahydrofuran; N,N-dimethyl-formamide
T=20°C; 18 h;
参考文献
HOFFMANN-LA ROCHE INC.; Aebi, Johannes; Amrein, Kurt; Hornsperger, Benoit; Kuhn, Bernd; Maerki, Hans P.; Mayweg, Alexander V.; Mohr, Peter; Tan, Xuefei
Patent: US2014/128429 A1, 2014 ;
Location in patent: Paragraph 0340; 0341 ;