3-氨基-2-氰基-2-丁烯硫代酰胺合成路线 （共 4 条）
反应条件
dihydrogen peroxide in methanol T=0°C; 4 h; Reflux;
参考文献
INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.
Patent: WO2013/25733 A1, 2013 ;
Location in patent: Paragraph 0436 ;
反应条件
ammonia in methanol
T=20°C;
参考文献
INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.
Patent: WO2013/25733 A1, 2013 ;
Location in patent: Paragraph 0435 ;
反应条件
1: triethylamine; hydrogen sulfide / tetrahydrofuran / 0.5 h / 0 °C
2: ammonia / methanol / 20 °C
View Scheme
参考文献
INTERMUNE, INC.; BUCKMAN, Brad, O.; NICHOLAS, John, B.; EMAYAN, Kumaraswamy; SEIWERT, Scott, D.
Patent: WO2013/25733 A1, 2013 ;
反应条件
1: aq. H2O2 / methanol
2: aq. H2O2, NH3
View Scheme
参考文献
Anderson,R.C.; Hsiao,Y.Y.
Journal of Heterocyclic Chemistry, 1975 , vol. 12, p. 883 - 887
