5-氨基-3-甲基异噻唑-4-羧酰胺合成路线 （共 2 条）
反应条件
1: With sulfuric acid in water
T=55 - 70°C; 1 h;
2: With ammonia in water
T=60 - 65°C; pH=10;
参考文献
AstraZeneca AB
Patent: US2006/41128 A1, 2006 ;
Location in patent: Page/Page column 22 ;
反应条件
1: aq. H2O2 / methanol
2: aq. H2O2, NH3
View Scheme
参考文献
Anderson,R.C.; Hsiao,Y.Y.
Journal of Heterocyclic Chemistry, 1975 , vol. 12, p. 883 - 887
