反应条件
1: (R)-4-(8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-ylamino)-3-methoxybenzoic acid With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; diisopropylamine in N,N-dimethyl-formamide T=20°C; 0.5 h; Inert atmosphere; 2: 1-methyl-piperidin-4-ylamine in N,N-dimethyl-formamide T=20°C; 3 h; Inert atmosphere;
参考文献
Budin, Ghyslain; Yang, Katherine S.; Reiner, Thomas; Weissleder, Ralph
Angewandte Chemie - International Edition, 2011 , vol. 50, # 40 p. 9378 - 9381