phosphorus tribromide in diethyl ether

ethylenediaminetetraacetic acid; phenyl-methyl-sulfonyl fluoride; water in aq. phosphate buffer T=30°C; Microbiological reactionEnzymatic reaction; Kinetics;

1.1: phosphorus pentachloride / CH2Cl2 / -10 - 20 °C 2.1: aluminum chloride / CH2Cl2 / 22 - 28 °C 2.2: aq. HCl / CH2Cl2 / -5 - 1 °C 3.1: 175 g / Red-Al; sodium bis(2-methoxyethoxy)aluminum hydride / toluene; tetrahydrofuran / -10 - 0 °C 4.1: pyridine / CH2Cl2 / -5 - 0 °C 5.1: 73 g / nitric acid; trifluoroacetic acid; trifluoroacetic anhydride / CH2Cl2 / -35 - -30 °C 6.1: 92.9 percent / NaOH; methanol / 23 °C 7.1: acetic acid; perchloric acid; hydrogen / Pd/C / 15.5 h / 2172.08 - 2585.81 Torr 7.2: NaHCO3 / H2O; CH2Cl2 / 23 °C / pH 8.0 View Scheme