4 -氟- 2 -碘硝基苯合成路线 (共 3 条)
反应条件
sodium azide; CuSO4‵5H2O; sodium carbonate; sodium L-ascorbate; L-proline in water; dimethyl sulfoxide T=70°C; 24 h;
参考文献
Goriya, Yogesh; Ramana
Tetrahedron, 2010 , vol. 66, # 38 p. 7642 - 7650
反应条件
hydrogenchloride; potassium iodide; sodium nitrite in water
T=0 - 20°C; 3 h;
参考文献
Kuntz, Kevin; Uehling, David Edward; Waterson, Alex Gregory; Emmitte, Kyle Allen; Stevens, Kirk; Shotwell, John Brad; Smith, Stephon Cornell; Nailor, Kristen E.; Salovich, James M.; Wilson, Brian John; Cheung, Mui; Mook, Robert Anthony; Baum, Erich W.; Moorthy, Ganesh
Patent: US2008/300242 A1, 2008 ;
Location in patent: Page/Page column 63 ;
US 20080300242 A1
反应条件
sulfuric acid; potassium nitrate
T=135°C; 4.5 h; Yield given. Yields of byproduct given;
参考文献
Nasielski-Hinkens, Raymonde; Leveque, Pierre; Castelet, Daniel; Nasielski, Jacques
Heterocycles, 1987 , vol. 26, # 9 p. 2433 - 2442