6-氨基-1,3-二丁基尿嘧啶合成路线 （共 7 条）
反应条件
sodium hydroxide; acetic anhydride in methanol
参考文献
The United States of America as represented by the Department of Health and Human Services
Patent: US5773423 A1, 1998 ;
US 5773423 A
反应条件
acetic anhydride Behandeln des Reaktionsprodukts mit wss.NaOH;
参考文献
Kalla, Rao V.; Elzein, Elfatih; Perry, Thao; Li, Xiaofen; Palle, Venkata; Varkhedkar, Vaibhav; Gimbel, Arthur; Maa, Tennig; Zeng, Dewan; Zablocki, Jeff
Journal of Medicinal Chemistry, 2006 , vol. 49, # 12 p. 3682 - 3692
反应条件
sodium hydroxide in methanol 0.5 h; Yield given;
参考文献
Kim, Hea Ok; Ji, Xiao-duo; Melman, Neli; Olah, Mark E.; Stiles, Gary L.; Jacobson, Kenneth A.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3373 - 3382
反应条件
1: acetic anhydride / 2 h / 80 °C 2: aq. NaOH / methanol / 0.5 h View Scheme
参考文献
Kim, Hea Ok; Ji, Xiao-duo; Melman, Neli; Olah, Mark E.; Stiles, Gary L.; Jacobson, Kenneth A.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3373 - 3382
反应条件
1: 82.6 percent / glacial acetic acid, aq. HCl, NaNO2 / H2O / 0.5 h 2: H2 / 5percent Pd/C / dimethylformamide / 2 h / 2585.7 Torr 3: 1.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 2.) aq. NaOH / 1.) DMF, RT, 3 h, 2.) reflux, 1 h View Scheme
参考文献
Kim, Hea Ok; Ji, Xiao-duo; Melman, Neli; Olah, Mark E.; Stiles, Gary L.; Jacobson, Kenneth A.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3373 - 3382
反应条件
hydrogenchloride; acetic acid; sodium nitrite in water 0.5 h;
参考文献
The United States of America as represented by the Department of Health and Human Services
Patent: US5773423 A1, 1998 ;
US 5773423 A
反应条件
1.1: aq. AcOH / 0.5 h / 75 °C
1.2: NaNO2 / 1 h / 20 °C
2.1: aq. NH3 / 0.5 h / 70 °C
2.2: Na2S2O4 / 0.5 h / 20 °C
View Scheme
参考文献
Kim, Hea Ok; Ji, Xiao-duo; Melman, Neli; Olah, Mark E.; Stiles, Gary L.; Jacobson, Kenneth A.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3373 - 3382
