(S)-4-硝基-Alpha-甲基苄胺合成路线 （共 16 条）
参考文献
Cope,A.C. et al.
Journal of the American Chemical Society, 1970 , vol. 92, # 5 p. 1243 - 1247
反应条件
1.1: hydroxylamine hydrochloride / water; methanol / 25 °C 2.1: sodium tetrahydroborate / water; acetonitrile / 0.17 h / 25 °C 3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C 3.2: 18 h / 20 °C 4.1: C19H23BNO3(1-)*H(1+); borane-THF / 1,4-dioxane; tetrahydrofuran / 0 °C / |Inert atmosphere View Scheme
参考文献
Ou, Wenhua; Espinosa, Sandraliz; Melendez, Hector J.; Farre, Silvia M.; Alvarez, Jaime L.; Torres, Valerie; Martinez, Ileanne; Santiago, Kiara M.; Ortiz-Marciales, Margarita
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5314 - 5327
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C 1.2: 18 h / 20 °C 2.1: C19H23BNO3(1-)*H(1+); borane-THF / 1,4-dioxane; tetrahydrofuran / 0 °C / |Inert atmosphere View Scheme
参考文献
Ou, Wenhua; Espinosa, Sandraliz; Melendez, Hector J.; Farre, Silvia M.; Alvarez, Jaime L.; Torres, Valerie; Martinez, Ileanne; Santiago, Kiara M.; Ortiz-Marciales, Margarita
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5314 - 5327
反应条件
Chromobacterium violaceum ω-transaminase variant W60C T=37°C; pH=7; 12 h; Reagent/catalystpH-value; enantioselective reaction;
参考文献
Wang, Bo; Land, Henrik; Berglund, Per
Chemical Communications, 2013 , vol. 49, # 2 p. 161 - 163
参考文献
Pallavicini, Marco; Valoti, Ermanno; Villa, Luigi; Piccolo, Oreste
Tetrahedron Asymmetry, 1996 , vol. 7, # 4 p. 1117 - 1122
反应条件
SnCl2·2H2O in ethyl acetate T=20°C;
参考文献
Fuchs, Klaus; Eickmeier, Christian; Heine, Niklas; Peters, Stefan; Dorner-Ciossek, Cornelia; Handschuh, Sandra; Nar, Herbert; Klinder, Klaus
Patent: US2010/144681 A1, 2010 ;
Location in patent: Page/Page column 64 ;
US 20100144681 A1
