(S)-(+)-1-甲基-3-苯基丙胺合成路线 （共 50 条）
反应条件
(i) HCONH2, (ii) aq. NaOH, (iii) (racemate resolution using tartaric acid); Multistep reaction;
参考文献
Koszelewski, Dominik; Lavandera, Ivan; Clay, Dorina; Rozzell, David; Kroutil, Wolfgang
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 17 p. 2761 - 2766
反应条件
[3H]-L-Alanine; Bacillus subtilis L-alanine dehydrogenase; NAD-specific formate dehydrogenase; ω-transaminase ATA-113; pyridoxal 5'-phosphate; ammonium formate; β-nicotinamide adenine dinucleotide in dimethyl sulfoxide T=30°C; pH=7; 24 h; aq. phosphate buffer; optical yield given as percent eeenantioselective reaction;
参考文献
Nugent, Thomas C.; Negru, Daniela E.; El-Shazly, Mohamed; Hu, Dan; Sadiq, Abdul; Bibi, Ahtaram; Umar, M. Naveed
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 11-12 p. 2085 - 2092
反应条件
hydrogen; palladium on activated charcoal in methanol P=2625.2 Torr; 12 h;
参考文献
Seljestokken, Bente; Fiksdahl, Anne
Acta Chemica Scandinavica, 1993 , vol. 47, # 10 p. 1050 - 1052
反应条件
Novozym 435 T=23°C; 1 h; Molecular sieveEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Paeivioe, Mari; Perkioe, Paeivi; Kanerva, Liisa T.
Tetrahedron Asymmetry, 2012 , vol. 23, # 3-4 p. 230 - 236
反应条件
pyridoxal 5'-phosphate in aq. phosphate buffer; dimethyl sulfoxide T=30°C; pH=7.5; 24 h; Resolution of racemateEnzymatic reaction; enantioselective reaction;
参考文献
Paeivioe, Mari; Kanerva, Liisa T.
Process Biochemistry, 2013 , vol. 48, # 10 p. 1488 - 1494
反应条件
pyridoxal 5'-phosphate; recombinant ω-transaminase from Burkholderia vietnamiensis G4 in aq. phosphate buffer T=37°C; pH=7.4; 12 h; Enzymatic reaction; enantioselective reaction;
参考文献
Jiang, Jinju; Chen, Xi; Feng, Jinhui; Wu, Qiaqing; Zhu, Dunming
Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 100, p. 32 - 39
反应条件
pyridoxal 5'-phosphate; recombinant ω-transaminase from Burkholderia vietnamiensis G4 in aq. phosphate buffer T=37°C; pH=7.4; 0.0833333 h; Enzymatic reaction; enantioselective reaction;
参考文献
Jiang, Jinju; Chen, Xi; Feng, Jinhui; Wu, Qiaqing; Zhu, Dunming
Journal of Molecular Catalysis B: Enzymatic, 2014 , vol. 100, p. 32 - 39
反应条件
hydrogen; palladium oxide on charcoal in ethanol P=2585.7 Torr; 20 h;
参考文献
Clifton; Collins; Hallett; Hartley; Lunts; Wicks
Journal of Medicinal Chemistry, 1982 , vol. 25, # 6 p. 670 - 679
反应条件
Vibrio fluvialis JS17; 2-oxo-propionic acid in phosphate buffer T=37°C; pH=7.0; Microbiological reaction; Enzyme kinetics; Further Variations:Reagents;
参考文献
El Blidi, Lahssen; Vanthuyne, Nicolas; Siri, Didier; Gastaldi, Stephane; Bertrand, Michele P.; Gil, Gerard
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 18 p. 4165 - 4168
反应条件
[bis(acetoxy)iodo]benzene in methanol T=22°C; 1 h;
参考文献
Porter; Traverse; Hoveyda; Snapper
Journal of the American Chemical Society, 2001 , vol. 123, # 42 p. 10409 - 10410
