(S)-(+)-1-甲基-3-苯基丙胺合成路线 （共 50 条）
反应条件
Candida antarctica lipase B in n-heptane T=80°C; 5 h;
参考文献
Nechab, Malek; Azzi, Nadia; Vanthuyne, Nicolas; Bertrand, Michele; Gastaldi, Stephane; Gil, Gerard
Journal of Organic Chemistry, 2007 , vol. 72, # 18 p. 6918 - 6923
反应条件
immobilized alkaline protease in 3-methyl pentan-3-ol T=21°C; 1 h; Enzymatic reaction; optical yield given as percent eediastereoselective reaction;
参考文献
El Blidi, Lahssen; Vanthuyne, Nicolas; Siri, Didier; Gastaldi, Stephane; Bertrand, Michele P.; Gil, Gerard
Organic and Biomolecular Chemistry, 2010 , vol. 8, # 18 p. 4165 - 4168
反应条件
Candida antarctica lipase B in n-heptane T=80°C; 1.5 h;
参考文献
Nechab, Malek; Azzi, Nadia; Vanthuyne, Nicolas; Bertrand, Michele; Gastaldi, Stephane; Gil, Gerard
Journal of Organic Chemistry, 2007 , vol. 72, # 18 p. 6918 - 6923
反应条件
Candida antarctica lipase B in n-heptane T=80°C; 9 h;
参考文献
Nechab, Malek; Azzi, Nadia; Vanthuyne, Nicolas; Bertrand, Michele; Gastaldi, Stephane; Gil, Gerard
Journal of Organic Chemistry, 2007 , vol. 72, # 18 p. 6918 - 6923
反应条件
Candida antarctica lipase B in n-heptane T=80°C; 7 h;
参考文献
Nechab, Malek; Azzi, Nadia; Vanthuyne, Nicolas; Bertrand, Michele; Gastaldi, Stephane; Gil, Gerard
Journal of Organic Chemistry, 2007 , vol. 72, # 18 p. 6918 - 6923
反应条件
1: 50 percent / NaH / tetrahydrofuran / 2 h / Heating 2: 98 percent / NaN3, NaI / dimethylformamide / 20 h / 120 °C 3: 70 percent / H2 / Pd/C / methanol / 12 h / 2625.2 Torr View Scheme
参考文献
Seljestokken, Bente; Fiksdahl, Anne
Acta Chemica Scandinavica, 1993 , vol. 47, # 10 p. 1050 - 1052
反应条件
1: 98 percent / NaN3, NaI / dimethylformamide / 20 h / 120 °C 2: 70 percent / H2 / Pd/C / methanol / 12 h / 2625.2 Torr View Scheme
参考文献
Seljestokken, Bente; Fiksdahl, Anne
Acta Chemica Scandinavica, 1993 , vol. 47, # 10 p. 1050 - 1052
反应条件
alkaline protease in tetrahydrofuran; 3-methyl pentan-3-ol T=18 - 24°C; Enzymatic reaction; optical yield given as percent ee;
参考文献
El Blidi, Lahssen; Nechab, Malek; Vanthuyne, Nicolas; Gastaldi, Stephane; Bertrand, Michele P.; Gil, Gerard
Journal of Organic Chemistry, 2009 , vol. 74, # 7 p. 2901 - 2903
反应条件
Candida antarctica lipase B in n-heptane T=80°C; 5 h;
参考文献
Nechab, Malek; Azzi, Nadia; Vanthuyne, Nicolas; Bertrand, Michele; Gastaldi, Stephane; Gil, Gerard
Journal of Organic Chemistry, 2007 , vol. 72, # 18 p. 6918 - 6923
反应条件
immobilized Properase 1600L in 3-methyl pentan-3-ol T=21°C; 0.75 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Queyroy, Severine; Vanthuyne, Nicolas; Gastaldi, Stephane; Bertrand, Michele P.; Gil, Gerard
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 9 p. 1759 - 1764
