(S)-(+)-1-甲基-3-苯基丙胺合成路线 （共 50 条）
反应条件
supported Candida antartica lipase B in tert-butyl methyl ether T=38 - 40°C; 2.5 h; Molecular sieveEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Poulhes, Florent; Vanthuyne, Nicolas; Bertrand, Michele P.; Gastaldi, Stephane; Gil, Gerard
Journal of Organic Chemistry, 2011 , vol. 76, # 17 p. 7281 - 7286
反应条件
(S)-α-alanine; pyridoxal 5'-phosphate; nicotinamide adenine dinucleotide; ammonium formate; alcohol dehydrogenase; lactate dehydrogenase in aq. phosphate buffer T=30°C; pH=7.5; 24 h; Enzymatic reaction;
参考文献
Tauber, Katharina; Fuchs, Michael; Sattler, Johann H.; Pitzer, Julia; Pressnitz, Desiree; Koszelewski, Dominik; Faber, Kurt; Pfeffer, Jan; Haas, Thomas; Kroutil, Wolfgang
Chemistry - A European Journal, 2013 , vol. 19, # 12 p. 4030 - 4035
反应条件
transaminase ATA-117; pyridoxal 5'-phosphate; sodium 2-oxopropanoate T=30°C; pH=7.0; 24 h; aq. phosphate bufferResolution of racemateEnzymatic reaction; optical yield given as percent ee;
参考文献
Koszelewski, Dominik; Clay, Dorina; Rozzell, David; Kroutil, Wolfgang
European Journal of Organic Chemistry, 2009 , # 14 p. 2289 - 2292
反应条件
immobilized alkaline protease in 3-methyl pentan-3-ol T=21°C; 0.666667 h; Enzymatic reaction; optical yield given as percent eediastereoselective reaction;
参考文献
Bottalla, Anne-Lise; Queyroy, Severine; Azzi-Schue, Nadia; Vanthuyne, Nicolas; Gastaldi, Stephane; Bertrand, Michele P.; Gil, Gerard
Tetrahedron Asymmetry, 2009 , vol. 20, # 24 p. 2823 - 2834
反应条件
immobilized Properase 1600L in 3-methyl pentan-3-ol T=21°C; 0.666667 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Bottalla, Anne-Lise; Queyroy, Severine; Azzi-Schue, Nadia; Vanthuyne, Nicolas; Gastaldi, Stephane; Bertrand, Michele P.; Gil, Gerard
Tetrahedron Asymmetry, 2009 , vol. 20, # 24 p. 2823 - 2834
反应条件
immobilized Properase 1600L in 3-methyl pentan-3-ol T=21°C; 1 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Bottalla, Anne-Lise; Queyroy, Severine; Azzi-Schue, Nadia; Vanthuyne, Nicolas; Gastaldi, Stephane; Bertrand, Michele P.; Gil, Gerard
Tetrahedron Asymmetry, 2009 , vol. 20, # 24 p. 2823 - 2834
反应条件
coated protease in 3-methyl pentan-3-ol T=21°C; 0.666667 h; Resolution of racemateEnzymatic reaction;
参考文献
Queyroy, Severine; Vanthuyne, Nicolas; Gastaldi, Stephane; Bertrand, Michele P.; Gil, Gerard
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 9 p. 1759 - 1764
反应条件
coated protease in 3-methyl pentan-3-ol T=21°C; 1.5 h; Resolution of racemateEnzymatic reaction;
参考文献
Queyroy, Severine; Vanthuyne, Nicolas; Gastaldi, Stephane; Bertrand, Michele P.; Gil, Gerard
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 9 p. 1759 - 1764
反应条件
sulfuric acid; N-trityl-aziridine diphenylcarbinol; potassium hydride 1.) PhCH3, 70 deg C, 60 min, 2.) PhCH3, 105 deg C; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Willems, Johannes G. H.
Tetrahedron Letters, 1995 , vol. 36, # 22 p. 3917 - 3920
反应条件
transaminase ATA-113; pyridoxal 5'-phosphate; sodium 2-oxopropanoate T=30°C; pH=7.0; 24 h; aq. phosphate bufferResolution of racemateEnzymatic reaction; optical yield given as percent ee;
参考文献
Koszelewski, Dominik; Clay, Dorina; Rozzell, David; Kroutil, Wolfgang
European Journal of Organic Chemistry, 2009 , # 14 p. 2289 - 2292
