1-苯基-2-丙炔-1-醇合成路线 （共 176 条）
反应条件
1: 68 percent / Et3N / (Ph3P)2PdCl2 / 24 h / 20 °C 2: 89 percent / p-toluenesulfonic acid / benzene / 48 h / 20 °C 3: aq. sodium hydroxide / ethanol / 40 h / 20 °C 4: phosphoric acid / acetic acid / 0.42 h / 90 °C View Scheme
参考文献
Kundu, Nitya G.; Mahanty, Jyan S.; Das, Palas; Das, Biswajit
Tetrahedron Letters, 1993 , vol. 34, # 10 p. 1625 - 1628
反应条件
1: CuBr; diisopropylamine / dioxane / Heating 2: 62 percent / LiBr; acetic acid / palladium(II) acetate / 1 h / 40 °C 3: 56 percent / triethylamine; pinacolborane; DPEphos / palladium(II) acetate / dioxane; tetrahydrofuran / 5 h / 100 °C View Scheme
参考文献
Tetrahedron, , vol. 63, # 45 p. 10939 - 10948
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / |Inert atmosphere 1.2: 1 h / -78 - -20 °C / |Inert atmosphere 1.3: 1 h / -20 - 20 °C / |Inert atmosphere 2.1: manganese(IV) oxide / acetone / 2 h / 20 °C / |Inert atmosphere 3.1: ethanol / 6 h / 20 °C / |Inert atmosphere 4.1: sodium azide; copper diacetate / methanol / 18 h / 55 °C 5.1: palladium 10 on activated carbon; hydrogen / methanol / 6 h / 20 °C View Scheme
参考文献
Kirkham, James D.; Edeson, Steven J.; Harrity, Joseph P. A.; Stokes, Stephen
Organic Letters, 2012 , vol. 14, # 20 p. 5354 - 5357,4
反应条件
trifluoroacetic acid; [Ru(η3-2-C3H4Me)(CO)(1,1'-(Ph2P)2-ferrocene)][SbF6] in tetrahydrofuran T=75°C; 3 h;
参考文献
Cadierno, Victorio; Gimeno, Jose; Nebra, Noel
Chemistry - A European Journal, 2007 , vol. 13, # 35 p. 9973 - 9981
反应条件
1: 90.8 percent / copper(I) iodide; pyridine; sodium carbonate / Pd(PPh3)2Cl2 / H2O / 0.12 h / 85 °C 2: 96.8 percent / CrO3*2Py / CH2Cl2 / 1.5 h / 20 °C View Scheme
参考文献
Barabanov; Fedenok; Polyakov; Shvartsberg
Russian Chemical Bulletin, 2001 , vol. 50, # 9 p. 1663 - 1667
反应条件
1.1: copper(l) iodide; tetrabutylammomium bromide; potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 23 - 25 °C / Inert atmosphere 1.2: 24 h / Inert atmosphere 2.1: manganese(IV) oxide / dichloromethane / 23 - 25 °C 3.1: methanol; toluene-4-sulfonic acid / 6 h / 75 °C View Scheme
参考文献
Yang, Fang; Ji, Ke-Gong; Zhao, Shu-Chun; Ali, Shaukat; Ye, Yu-Ying; Liu, Xue-Yuan; Liang, Yong-Min
Chemistry - A European Journal, 2012 , vol. 18, # 21 p. 6470 - 6474
反应条件
triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide in tetrahydrofuran Phenylation; Sonogashira coupling; Heating;
参考文献
Angewandte Chemie - International Edition, , vol. 39, # 7 p. 1253 - 1256
反应条件
1: With silica gel in dichloromethane 2: 0.1 h; Microwave irradiationNeat (no solvent);
参考文献
Chen, Qing-Zhen; Ding, Zong-Cang; Ma, Yan-Li; Wang, Zhen-Dong; Zhan, Zhuang-Ping
Heterocycles, 2012 , vol. 85, # 8 p. 1891 - 1896
反应条件
1: 21 percent / AcONa, CuCl2 / PdCl2 2: 65 percent / Bu3N, HCOOH / Pd(OAc)2*3(PPh2) / dimethylformamide / 4 h / 60 °C View Scheme
参考文献
Arcadi, A.; Bernocchi, E.; Burini, A.; Cacchi, S.; Marinelli, F.; Pietroni, B.
Tetrahedron, 1988 , vol. 44, # 2 p. 481 - 490
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in toluene T=0 - 20°C; Mitsunobu reaction; 1.5 h; Inert atmosphere;
参考文献
Anderson, James C.; McCarthy, Robert A.; Paulin, Sarah; Taylor, Peter W.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 23 p. 6996 - 7000
