1-苯基-2-丙炔-1-醇合成路线 （共 176 条）
反应条件
(i) PhLi, Et2O, (ii) /BRN= 774156/, Py; Multistep reaction;
参考文献
Horner,L.; Binder,V.
Justus Liebigs Annalen der Chemie, 1972 , vol. 757, p. 33 - 68
反应条件
1: (i) EtMgBr, Et2O, (ii) /BRN= 471223/, THF
2: MnO2 / acetone
View Scheme
参考文献
Iwai,I.; Tomita,K.
Chemical and Pharmaceutical Bulletin, 1963 , vol. 11, p. 524 - 528
反应条件
Bi(NO3)3·5H2O; 3-butyl-1-ethyl-4-nitroimidazolium bis(trifluoromethylsulfonyl)imide
T=20 - 60°C; 10.1667 h; Inert atmosphere;
参考文献
Aridoss, Gopalakrishnan; Laali, Kenneth K.
Tetrahedron Letters, 2011 , vol. 52, # 51 p. 6859 - 6864
反应条件
mercury(II) diacetate in tetrahydrofuran
T=60°C; 14 h;
参考文献
Barluenga, Jose; Aznar, Fernando; Liz, Ramon; Cabal, Maria-Paz
Synthesis, 1985 , # 3 p. 313 - 314
反应条件
zinc trifluoromethanesulfonate in toluene
T=100°C;
参考文献
Kumar, Manyam Praveen; Liu, Rai-Shung
Journal of Organic Chemistry, 2006 , vol. 71, # 13 p. 4951 - 4955
反应条件
1: 68 percent / Et3N / (Ph3P)2PdCl2 / 24 h / 20 °C
2: 5 percent / LiCl; K2CO3 / Pd(OAc)2 / dimethylformamide / 16 h / 100 °C
View Scheme
参考文献
Mahanty, Jyan S.; De, Mahuya; Das, Palas; Kundu, Nitya G.
Tetrahedron, 1997 , vol. 53, # 39 p. 13397 - 13418
参考文献
G. D. Searle and Co.
Patent: US4822775 A1, 1989 ;
反应条件
T=-40 - 20°C; Inert atmosphere;
参考文献
Cheng, Xin; Jiang, Xuefeng; Yu, Yihua; Ma, Shengming
Journal of Organic Chemistry, 2008 , vol. 73, # 22 p. 8960 - 8965
反应条件
1: NaH, pyrrolidin-2-one / dimethylsulfoxide / 2 h / 90 °C
2: 68 percent / 10percent Pd/C / 23 h / 215 °C
3: 51 percent / SeO2 / 0.5 h / 210 °C
View Scheme
参考文献
Rose; Statham
Journal of the Chemical Society, 1950 , p. 69
反应条件
zinc trifluoromethanesulfonate; TpRu(PPh3)(CH3CN)2PF6 in toluene
T=100°C; 5 h;
参考文献
Kumar, Manyam Praveen; Liu, Rai-Shung
Journal of Organic Chemistry, 2006 , vol. 71, # 13 p. 4951 - 4955
