1-苯基-2-丙炔-1-醇合成路线 （共 176 条）
反应条件
ruthenium cyclopentadienone complex (C34H24N2O4Ru) in toluene
T=100°C; 5 h; Product distribution; Further Variations:Catalysts;
参考文献
Haak, Edgar
European Journal of Organic Chemistry, 2007 , # 17 p. 2815 - 2824
参考文献
Logemann et al.
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1955 , vol. 298, p. 87,91
Show Details
Iwai et al.
Yakugaku Zasshi, 1960 , vol. 80, p. 156
Chem.Abstr., 1960 , vol. 54, # 13061
反应条件
tris[fac-2-phenylpyridinato-C2,N]iridium(III); 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran; acetonitrile
T=20°C; Sealed tubeInert atmosphereIrradiation;
参考文献
Iqbal, Naeem; Jung, Jaehun; Park, Sehyun; Cho, Eun Jin
Angewandte Chemie - International Edition, 2014 , vol. 53, # 2 p. 539 - 542
Angew. Chem., 2014 , vol. 126, # 2 p. 549 - 552
反应条件
1: 73 percent / copper(I) cyanide; lithium chloride / diethyl ether / 18 h / 20 °C
View Scheme
参考文献
Mentink, Gertjan; Van Maarseveen, Jan H.; Hiemstra, Henk
Organic Letters, 2002 , vol. 4, # 20 p. 3497 - 3500
反应条件
1: para-nitro iodo-benzene; 3-hydroxy-3-phenyl-prop-1-yne With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in tetrahydrofuran
Sonogashira coupling; 16 h; Heating;
2: 1,2-diamino-benzene With triethylamine in tetrahydrofuran
24 h; Heating;
参考文献
Braun, Roland U.; Zeitler, Kirsten; Mueller, Thomas J. J.
Organic Letters, 2000 , vol. 2, # 26 p. 4181 - 4184
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine in tetrahydrofuran
T=100°C; 0.5 h; Inert atmosphereMicrowave irradiation; Reagent/catalystSolventTemperature;
参考文献
Wang, Yuqin; Tan, Cun; Zhang, Xiaofei; He, Qian; Xie, Yuyuan; Yang, Chunhao
European Journal of Organic Chemistry, 2012 , # 33 p. 6622 - 6629,8
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine in tetrahydrofuran
T=100°C; 0.5 h; Inert atmosphereMicrowave irradiation;
参考文献
Wang, Yuqin; Tan, Cun; Zhang, Xiaofei; He, Qian; Xie, Yuyuan; Yang, Chunhao
European Journal of Organic Chemistry, 2012 , # 33 p. 6622 - 6629,8
反应条件
BaMnO4 in ethanol; acetic acid
T=170°C; Bohlmann-Rahtz reaction; 0.75 h; Microwave irradiation;
参考文献
Bagley, Mark C.; Lin, Zhifan; Pope, Simon J. A.
Chemical Communications, 2009 , # 34 p. 5165 - 5167
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / |Inert atmosphere
1.2: 1 h / -78 - -20 °C / |Inert atmosphere
1.3: 1 h / -20 - 20 °C / |Inert atmosphere
2.1: manganese(IV) oxide / acetone / 2 h / 20 °C / |Inert atmosphere
3.1: ethanol / 8 h / 20 °C / |Inert atmosphere
4.1: sodium carbonate / water / 4 h / |Reflux
View Scheme
参考文献
Kirkham, James D.; Edeson, Steven J.; Harrity, Joseph P. A.; Stokes, Stephen
Organic Letters, 2012 , vol. 14, # 20 p. 5354 - 5357,4
反应条件
1: para-bromobenzonitrile; 3-hydroxy-3-phenyl-prop-1-yne With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine
Sonogashira coupling; 16 h; Heating;
2: benzaldehyde With N-methyl-4-methyl-5-(2-hydroxyethyl)thiazolin iodide in triethylamine
Stetter reaction; 8 h; Heating;
3: With 2-amino-acetamide in acetic acid; triethylamine
Paal-Knorr reaction; 120 h; Heating; Further stages.;
参考文献
Braun, Roland U.; Zeitler, Kirsten; Mueller, Thomas J. J.
Organic Letters, 2001 , vol. 3, # 21 p. 3297 - 3300
