1-苯基-2-丙炔-1-醇合成路线 （共 176 条）
反应条件
1: Et3N; CuI / (Ph3P)2PdCl2 / 14 h / Heating
2: 285 mg / Et3N; 3,4-dimethyl-5-(2-hydroxyethyl)thiazolium iodide / tetrahydrofuran / 24 h / Heating
3: 224 mg / aq. NH4Cl; AcOH / 30 h / Heating
View Scheme
参考文献
Braun, Roland U.; Mueller, Thomas J. J.
Synthesis, 2004 , # 14 p. 2391 - 2406
反应条件
1: para-bromobenzonitrile; 3-hydroxy-3-phenyl-prop-1-yne With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine
Sonogashira coupling; 16 h; Heating;
2: benzaldehyde With N-methyl-4-methyl-5-(2-hydroxyethyl)thiazolin iodide in triethylamine
Stetter reaction; 8 h; Heating; Further stages.;
参考文献
Braun, Roland U.; Zeitler, Kirsten; Mueller, Thomas J. J.
Organic Letters, 2001 , vol. 3, # 21 p. 3297 - 3300
反应条件
1: Et3N; CuI / (Ph3P)2PdCl2 / 14 h / Heating
2: 285 mg / Et3N; 3,4-dimethyl-5-(2-hydroxyethyl)thiazolium iodide / tetrahydrofuran / 24 h / Heating
View Scheme
参考文献
Braun, Roland U.; Mueller, Thomas J. J.
Synthesis, 2004 , # 14 p. 2391 - 2406
反应条件
trifluoroacetic acid; [Ru(η3-2-C3H4Me)(CO)(1,1'-(Ph2P)2-ferrocene)][SbF6]
T=75°C; 5 h;
参考文献
Cadierno, Victorio; Gimeno, Jose; Nebra, Noel
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 3 p. 382 - 394
反应条件
HAuCl4*3H2O in acetonitrile
T=60°C; 5 h;
参考文献
Arcadi, Antonio; Alfonsi, Maria; Chiarini, Marco; Marinelli, Fabio
Journal of Organometallic Chemistry, 2009 , vol. 694, # 4 p. 576 - 582
反应条件
Bi(NO3)3·5H2O; 3-butyl-1-ethyl-4-nitroimidazolium bis(trifluoromethylsulfonyl)imide
T=20 - 60°C; 9.16667 h; Inert atmosphere;
参考文献
Aridoss, Gopalakrishnan; Laali, Kenneth K.
Tetrahedron Letters, 2011 , vol. 52, # 51 p. 6859 - 6864
反应条件
NH4BF4; [(η5-C5Me5)RuCl(μ2-SMe)2Ru(η5-C5Me5)Cl]; platinum (II) chloride
36 h; Heating;
参考文献
Nishibayashi, Yoshiaki; Yoshikawa, Masato; Inada, Youichi; Milton, Marilyn Daisy; Hidai, Masanobu; Uemura, Sakae
Angewandte Chemie - International Edition, 2003 , vol. 42, # 23 p. 2681 - 2684
反应条件
1: 86 percent / Pd(PPh3)2Cl2; CuI; Et3N / dimethylformamide / 24 h / 20 °C
2: 73 percent / p-toluenesulfonic acid / benzene / 24 h / 20 °C
View Scheme
参考文献
De, Mahuya; Majumdar, Dyuti P.; Kundu, Nitya G.
Journal of the Indian Chemical Society, 1999 , vol. 76, # 11-12 p. 665 - 674
反应条件
1: 3-hydroxy-3-phenyl-prop-1-yne With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 22°C;
2: chloro-trimethyl-silane in tetrahydrofuran; hexane
T=-78 - 22°C; Further stages.;
参考文献
Kacprzynski, Monica A.; Kazane, Stephanie A.; May, Tricia L.; Hoveyda, Amir H.
Organic Letters, 2007 , vol. 9, # 16 p. 3187 - 3190
反应条件
boron fluoride ether; mercury(II) oxide; trichloroacetic acid
optically inactive stereoisomer(ic) of mp: 261 degree;
参考文献
Hennion; Murray
Journal of the American Chemical Society, 1942 , vol. 64, p. 1220
