1-苯基-2-丙炔-1-醇合成路线 （共 176 条）
反应条件
boron trifluoride diethyl etherate
参考文献
Kirmse,W.; Engelmann,A.
Chemische Berichte, 1973 , vol. 106, p. 3086 - 3091
反应条件
1: N,N,N',N,-tetramethylethylenediamine; oxygen; copper(l) chloride / acetone / 2 h / 20 °C
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 4 h / 60 °C / Inert atmosphere
View Scheme
参考文献
Wang, Ya-Hui; Liu, Heng; Zhu, Li-Li; Li, Xiao-Xiao; Chen, Zili
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 5 p. 707 - 712
反应条件
vanadium-montmorillonite in xylene
2.5 h; Heating;
参考文献
Choudary; Durga Prasad; Valli
Tetrahedron Letters, 1990 , vol. 31, # 51 p. 7521 - 7522
反应条件
polyvanadioorganosiloxane (4percent vanadium) in xylene
T=145 - 148°C;
参考文献
Gulyi, S. E.; Erman, M. B.; Novikov, N. A.; Aul'chenko, I. S.; Vol'pin, M. E.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, # 4 p. 715 - 721
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 4 p. 808 - 815
反应条件
1: para-nitro iodo-benzene; 3-hydroxy-3-phenyl-prop-1-yne With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in tetrahydrofuran
Sonogashira coupling; 16 h; Heating;
2: 2-amino-benzenethiol With acetic acid; triethylamine in tetrahydrofuran
20 h; Heating;
参考文献
Braun, Roland U.; Zeitler, Kirsten; Mueller, Thomas J. J.
Organic Letters, 2000 , vol. 2, # 26 p. 4181 - 4184
反应条件
titanium(III) chloride; methyllithium in ethylene glycol dimethyl ether; diethyl ether
Further byproducts given;
参考文献
Coulomb-Delbecq,F.; Gore,J.
Bulletin de la Societe Chimique de France, 1976 , p. 541 - 549
反应条件
silver hexafluoroantimonate; dichloro(pyridine-2-carboxylato)gold(III)
T=50°C; 0.666667 h; Molecular sieve; regioselective reaction;
参考文献
Xu, Cheng-Fu; Xu, Mei; Yang, Liu-Qing; Li, Chuan-Ying
Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 3010 - 3016
反应条件
1: 67 percent / Et3N / Pd(Ph3P)2Cl2, CuI / dimethylformamide / 1.) r.t., 1 h, 2.) 80 deg C, 24 h
2: 91 percent / manganese dioxide / CH2Cl2 / 24 h / Ambient temperature
View Scheme
参考文献
Kundu, Nitya G.; Pal, Manojit; Mahanty, Jyan S.; De, Mahuya
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 19 p. 2815 - 2820
反应条件
anschliessendes Behandeln mit CO2;
参考文献
Jones et al.
Journal of the Chemical Society, 1950 , p. 236,240
反应条件
1.1: toluene-4-sulfonic acid / dichloromethane / 20 °C
2.1: n-butyllithium / tetrahydrofuran / -78 - 20 °C
3.1: manganese(IV) oxide / dichloromethane / 0 - 20 °C
3.2: 50 °C
4.1: iodine / methanol / 5 h / 20 °C
5.1: tetrakis(triphenylphosphine) palladium(0); lithium chloride / N,N-dimethyl-formamide / 100 °C
6.1: Grubb's 2nd generation catalyst / dichloromethane / Reflux
View Scheme
参考文献
Yang, Fan; Jin, Tienan; Bao, Ming; Yamamoto, Yoshinori
Tetrahedron, 2011 , vol. 67, # 52 p. 10147 - 10155
