1-苯基-2-丙炔-1-醇合成路线 （共 176 条）
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / |Inert atmosphere 1.2: 1 h / -78 - -20 °C / |Inert atmosphere 1.3: 1 h / -20 - 20 °C / |Inert atmosphere 2.1: manganese(IV) oxide / acetone / 2 h / 20 °C / |Inert atmosphere 3.1: hydrazine hydrate / ethanol / 2 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Kirkham, James D.; Edeson, Steven J.; Harrity, Joseph P. A.; Stokes, Stephen
Organic Letters, 2012 , vol. 14, # 20 p. 5354 - 5357,4
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / |Inert atmosphere 1.2: 1 h / -78 - -20 °C / |Inert atmosphere 1.3: 1 h / -20 - 20 °C / |Inert atmosphere 2.1: manganese(IV) oxide / acetone / 2 h / 20 °C / |Inert atmosphere 3.1: ethanol / 6 h / 20 °C / |Inert atmosphere 4.1: sodium carbonate / water / 4 h / |Reflux View Scheme
参考文献
Kirkham, James D.; Edeson, Steven J.; Harrity, Joseph P. A.; Stokes, Stephen
Organic Letters, 2012 , vol. 14, # 20 p. 5354 - 5357,4
反应条件
1: With potassium hydride in 1,4-dioxane 2: With niobium pentafluoride in 1,4-dioxane
参考文献
Ravikumar; Yao, Lihua; Fleming, Fraser F.
Journal of Organic Chemistry, 2009 , vol. 74, # 19 p. 7294 - 7299
反应条件
trifluoroacetic acid
参考文献
Hudlicky,M.
Collection of Czechoslovak Chemical Communications, 1960 , vol. 25, p. 1199 - 1209
反应条件
pyridine; chloroform
参考文献
Logemann et al.
Farmaco, Edizione Scientifica, 1953 , vol. 8, p. 406,409
反应条件
(i) Py, CH2Cl2, (ii) liq. NH3; Multistep reaction;
参考文献
Dillard,R.D. et al.
Journal of Medicinal Chemistry, 1967 , vol. 10, p. 40 - 44
反应条件
zinc trifluoromethanesulfonate in toluene T=100°C;
参考文献
Kumar, Manyam Praveen; Liu, Rai-Shung
Journal of Organic Chemistry, 2006 , vol. 71, # 13 p. 4951 - 4955
反应条件
acetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in dimethyl sulfoxide T=65°C;
参考文献
Bagley, Mark C.; Hughes, David D.; Sabo, Halima M.; Taylor, Paul H.; Xiong, Xin
Synlett, 2003 , # 10 p. 1443 - 1446
反应条件
1: 99 percent / o-iodoxybenzoic acid / dimethylsulfoxide / 5 h / 20 °C 2: 86 percent / ZnBr2 / toluene / 6 h / Heating View Scheme
参考文献
Bagley, Mark C.; Brace, Christian; Dale, James W.; Ohnesorge, Maren; Phillips, Nathan G.; Xiong, Xin; Bower, Justin
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 14 p. 1663 - 1671
反应条件
[Cp*Ru{PhP(C6H4-o-S)2}RuCp*](OTf)2; isopropyl alcohol in 1,2-dichloro-ethane T=60°C; 2 h;
参考文献
Yuki, Masahiro; Miyake, Yoshihiro; Nishibayashi, Yoshiaki
Organometallics, 2010 , vol. 29, # 22 p. 5994 - 6001
