3-氰基-6-羟基-2-甲基吡啶合成路线 （共 9 条）
反应条件
in N,N-dimethyl-formamide T=20°C; 73 h; Reflux;
参考文献
CUSHMAN, Mark S.; KISELEV, Evgeny A.; MORRELL, Andrew E.
Patent: US2014/18360 A1, 2014 ;
Location in patent: Paragraph 0160 ;
反应条件
in dowtherm A; N,N-dimethyl-formamide T=25 - 230°C; Reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2010/261687 A1, 2010 ;
Location in patent: Page/Page column 56 ;
反应条件
in propynoic acid methyl ester
参考文献
AMERICAN CYANAMID COMPANY
Patent: EP446604 A2, 1991 ;
反应条件
in N,N-dimethyl-formamide 1) r.t., 1 h, 2) reflux, 72 h;
参考文献
Singh; Lesher; Brundage
Synthesis, 1991 , # 10 p. 894 - 896
反应条件
1: 87 percent / dimethylformamide / 4 h / 110 - 115 °C 2: 94 percent / HBr gas / CHCl3; acetic acid / Ambient temperature View Scheme
参考文献
Singh, Baldev; Lesher, George Y.; Pluncket, Kevin C.; Pagani, Edward D.; Bode, Donald C.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 26 p. 4858 - 4865
反应条件
trichlorophosphate 1.5 h; Heating;
参考文献
Singh; Lesher; Brundage
Synthesis, 1991 , # 10 p. 894 - 896
反应条件
1: 91 percent / POCl3 / 1.5 h / Heating 2: 96 percent / methanol / 0.5 h / Heating View Scheme
参考文献
CUSHMAN, Mark S.; KISELEV, Evgeny A.; MORRELL, Andrew E.
Patent: US2014/18360 A1, 2014 ;
反应条件
1: trichlorophosphate / 6 h / Reflux 2: 5 Pd(II)/C(eggshell); ammonium formate / methanol / 12 h / 20 °C View Scheme
参考文献
CUSHMAN, Mark S.; KISELEV, Evgeny A.; MORRELL, Andrew E.
Patent: US2014/18360 A1, 2014 ;
反应条件
1: trichlorophosphate / 6 h / |Reflux 2: ammonium formate; 5 palladium on charcoal / methanol / 12 h / 23 °C 3: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / 1,2-dichloro-ethane / 9 h / |Reflux View Scheme
