反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0 °C 1.2: 0 - 20 °C 2.1: caesium carbonate / N,N-dimethyl-formamide / 21 h / 60 °C 3.1: lithium hydroxide hydrate / tetrahydrofuran; methanol; water / 20 °C 4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane 5.1: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 20 °C View Scheme
参考文献
Brown, Matthew F.; Reilly, Usa; Abramite, Joseph A.; Arcari, Joel T.; Oliver, Robert; Barham, Rose A.; Che, Ye; Chen, Jinshan Michael; Collantes, Elizabeth M.; Chung, Seung Won; Desbonnet, Charlene; Doty, Jonathan; Doroski, Matthew; Engtrakul, Juntyma J.; Harris, Thomas M.; Huband, Michael; Knafels, John D.; Leach, Karen L.; Liu, Shenping; Marfat, Anthony; Marra, Andrea; McElroy, Eric; Melnick, Michael; Menard, Carol A.; Montgomery, Justin I.; Mullins, Lisa; Noe, Mark. C.; O'Donnell, John; Penzien, Joseph; Plummer, Mark S.; Price, Loren M.; Shanmugasundaram, Veerabahu; Thoma, Christy; Uccello, Daniel P.; Warmus, Joseph S.; Wishka, Donn G.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 914 - 923