triethylsilane; triethylamine; palladium diacetate in dichloromethane T=23°C; Hydrogenolysis; 12 h;

potassium carbonate in N,N-dimethyl-formamide T=70°C; 12 h; Inert atmosphere;

potassium carbonate; sodium iodide in acetone 5 h; Heating;

potassium carbonate in acetonitrile Heating;

1: boron tribromide / dichloromethane / 2 h / -78 - 20 °C 2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C View Scheme

sulfuric acid; dihydrogen peroxide; potassium bromide weiteres Reagens: Aethanol;

1: With n-butyllithium in diethyl ether; hexane T=0°C; 1.5 h; 2: With boric acid trimethyl ester in diethyl ether; hexane T=20°C; 3: With hydrogenchloride in diethyl ether; hexane T=20°C; 1.5 h;

1: With n-butyllithium in diethyl ether; hexane T=-78 - 0°C; Metallation; lithiation; 2: With boric acid trimethyl ester in diethyl ether; hexane T=-78 - 20°C; Substitution; 3: With hydrogenchloride in diethyl ether; hexane; water T=20°C; Hydrolysis; 0.75 h; Title compound not separated from byproducts;