5.6-二甲氧基-2-甲基茚酮合成路线 （共 16 条）
反应条件
scandium tris(trifluoromethanesulfonate) in nitromethane T=100°C; Friedel-Crafts acylation; 0.75 h;
参考文献
Fillion, Eric; Fishlock, Dan; Wilsily, Ashraf; Goll, Julie M.
Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1316 - 1327
反应条件
diisopropylamine; lithium diisopropyl amide; methyl iodide in tetrahydrofuran; cyclohexane; ethyl acetate
参考文献
Oxis International S.A.
Patent: US5543298 A1, 1996 ;
反应条件
1: 76 percent / K2CO3 / dimethylformamide 2: 77 percent / Sc(OTf)3 / nitromethane / 0.75 h / 100 °C View Scheme
参考文献
Fillion, Eric; Lou, Tiantong; Liao, E-Ting; Wilsily, Ashraf
Organic Syntheses, 2012 , vol. 89, p. 115 - 125
反应条件
hydrogen; palladium on activated charcoal in methanol
参考文献
Bodendorf,K.; Mayer,R.
Chemische Berichte, 1965 , vol. 98, p. 3565 - 3570
反应条件
sodium hydroxide; hydrogen; palladium on activated charcoal in methanol
参考文献
Bodendorf,K.; Mayer,R.
Chemische Berichte, 1965 , vol. 98, p. 3565 - 3570
反应条件
1: aq. HCl, NaOAc 2: H2 / Pd-C / methanol View Scheme
参考文献
Bodendorf,K.; Mayer,R.
Chemische Berichte, 1965 , vol. 98, p. 3565 - 3570
反应条件
1: HCl / diethyl ether 2: H2, aq. NaOH / Pd-C / methanol View Scheme
参考文献
Bodendorf,K.; Mayer,R.
Chemische Berichte, 1965 , vol. 98, p. 3565 - 3570
反应条件
1.1: piperidinium acetate / ethanol / 0.5 h 1.2: 77 percent / NaBH3CN / ethanol / 0 - 20 °C 2.1: 76 percent / K2CO3 / dimethylformamide 3.1: 77 percent / Sc(OTf)3 / nitromethane / 0.75 h / 100 °C View Scheme
参考文献
Fillion, Eric; Lou, Tiantong; Liao, E-Ting; Wilsily, Ashraf
Organic Syntheses, 2012 , vol. 89, p. 115 - 125
反应条件
1: sodium tris(acetoxy)borohydride / ethanol / 3 h / 20 °C / |Schlenk technique; |Inert atmosphere 2: potassium carbonate / N,N-dimethyl-formamide / 3.5 h / |Schlenk technique; |Inert atmosphere 3: trimethylsilyl trifluoromethanesulfonate / nitromethane / 1 h / 100 °C / |Schlenk technique; |Inert atmosphere View Scheme
参考文献
Fillion, Eric; Lou, Tiantong; Liao, E-Ting; Wilsily, Ashraf
Organic Syntheses, 2012 , vol. 89, p. 115 - 125
反应条件
PPA T=70 - 80°C; 12 h;
参考文献
Tashmukhamedova, A. K.; Sarieva, G. M.; Levkovich, M. G.; Kamaev, F. G.
Chemistry of Natural Compounds, 1983 , vol. 19, # 4 p. 489 - 492
Khimiya Prirodnykh Soedinenii, 1983 , vol. 19, # 4 p. 519 - 522
