2-(4-苯基-1-哌啶基)乙胺合成路线 （共 5 条）
反应条件
1: sodium iodide; sodium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C
2: hydrazine hydrate / ethanol / 2 h / 70 °C
View Scheme
参考文献
Lee, Ju-Hyeon; Seo, Seon Hee; Lim, Eun Jeong; Cho, Nam-Chul; Nam, Ghilsoo; Kang, Soon Bang; Pae, Ae Nim; Jeong, Nakcheol; Keum, Gyochang
European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 246 - 257
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 2 h / 20 °C
1.3: 15 h / -78 - 20 °C
2.1: palladium on activated charcoal; hydrogen / methanol / 15 h / 20 °C
3.1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C
4.1: sodium iodide; sodium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C
5.1: hydrazine hydrate / ethanol / 2 h / 70 °C
View Scheme
参考文献
Lee, Ju-Hyeon; Seo, Seon Hee; Lim, Eun Jeong; Cho, Nam-Chul; Nam, Ghilsoo; Kang, Soon Bang; Pae, Ae Nim; Jeong, Nakcheol; Keum, Gyochang
European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 246 - 257
反应条件
1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C
2: sodium iodide; sodium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C
3: hydrazine hydrate / ethanol / 2 h / 70 °C
View Scheme
参考文献
Lee, Ju-Hyeon; Seo, Seon Hee; Lim, Eun Jeong; Cho, Nam-Chul; Nam, Ghilsoo; Kang, Soon Bang; Pae, Ae Nim; Jeong, Nakcheol; Keum, Gyochang
European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 246 - 257
反应条件
1: palladium on activated charcoal; hydrogen / methanol / 15 h / 20 °C
2: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C
3: sodium iodide; sodium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C
4: hydrazine hydrate / ethanol / 2 h / 70 °C
View Scheme
参考文献
Lee, Ju-Hyeon; Seo, Seon Hee; Lim, Eun Jeong; Cho, Nam-Chul; Nam, Ghilsoo; Kang, Soon Bang; Pae, Ae Nim; Jeong, Nakcheol; Keum, Gyochang
European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 246 - 257
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 2 h / 20 °C
1.3: 15 h / -78 - 20 °C
2.1: palladium on activated charcoal; hydrogen / methanol / 15 h / 20 °C
3.1: trifluoroacetic acid / dichloromethane / 5 h / 0 - 20 °C
4.1: sodium iodide; sodium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C
5.1: hydrazine hydrate / ethanol / 2 h / 70 °C
View Scheme
参考文献
Lee, Ju-Hyeon; Seo, Seon Hee; Lim, Eun Jeong; Cho, Nam-Chul; Nam, Ghilsoo; Kang, Soon Bang; Pae, Ae Nim; Jeong, Nakcheol; Keum, Gyochang
European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 246 - 257
