S)-(-)-2-甲氧基丙酸乙酯合成路线 (共 11 条)
反应条件
silver(l) oxide in acetonitrile Methylation; 5 h; Heating;
参考文献
Barrett, Anthony G. M.; Braddock, D. Christopher; Christian, Paul W. N.; Pilipauskas, Daniel; White, Andrew J. P.; Williams, David J.
Journal of Organic Chemistry, 1998 , vol. 63, # 17 p. 5818 - 5823
反应条件
1: (S)-lactic acid ethyl ester With sodium hydride in tetrahydrofuran T=0°C; 0.5 h; 2: methyl halide in tetrahydrofuran T=0 - 20°C; 12.75 h;
参考文献
Jamieson, Andrew G.; Sutherland, Andrew
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 5 p. 735 - 736
反应条件
tetrafluoroboric acid in diethyl ether T=-10°C; Methylation; 2 h;
参考文献
Weber; Kreuzig; Bahadir
Chemosphere, 1997 , vol. 35, # 1-2 p. 13 - 20
反应条件
sodium hydride in diethyl ether T=-10 - 0°C; Methylation;
参考文献
Kobayashi, Kimiko; Kato, Takayuki; Unno, Masafumi; Masuda, Shinji
Bulletin of the Chemical Society of Japan, 1997 , vol. 70, # 6 p. 1393 - 1401
反应条件
silver(l) oxide T=50°C;
参考文献
Stevens; Deans
Canadian Journal of Research, Section B: Chemical Sciences, 1939 , vol. 17, p. 290
反应条件
sodium 1.) THF, 2.) from -78 deg C to RT; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Brookhart, Maurice; Liu, Yumin; Goldman, Emma W.; Timmers, Debra A.; Williams, Gregory D.
Journal of the American Chemical Society, 1991 , vol. 113, # 3 p. 927 - 939
反应条件
sodium hydride in diethyl ether 2 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Terfort, Andreas; Brunner, Henri
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 12 p. 1467 - 1479
反应条件
in ethanol 3 h; Heating;
参考文献
Bales; Horner; Huang; Newcomb; Crich; Greenberg
Journal of the American Chemical Society, 2001 , vol. 123, # 16 p. 3623 - 3629
反应条件
lithium aluminium tetrahydride
参考文献
Steudel, Annette; Stehr, Jens; Siebel, Eric; Fischer, R. Dieter
Journal of Organometallic Chemistry, 1998 , vol. 570, # 1 p. 89 - 96
反应条件
diisobutylaluminium hydride
参考文献
Pomeisl, Karel; Cejka, Jan; Kvicala, Jaroslav; Paleta, Oldrich
European Journal of Organic Chemistry, 2007 , # 35 p. 5917 - 5925