邻苯二甲酰基-L-丙氨酸合成路线 （共 17 条）
反应条件
1.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 4 h / |Reflux 2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -20 °C 3.1: palladium diacetate; CuF2; N,N'-dimethyl-N,N'-propyleneurea / acetone / 24 h / 100 °C / |Inert atmosphere; |Schlenk technique 4.1: sodium nitrite; acetic acid / acetic anhydride / 48.5 h / -15 °C 4.2: 2 h / -15 °C 4.3: 2 h / 0 °C View Scheme
参考文献
Zhang, Qi; Chen, Kai; Rao, Weihao; Zhang, Yuejun; Chen, Fa-Jie; Shi, Bing-Feng
Angewandte Chemie - International Edition, 2013 , vol. 52, # 51 p. 13588 - 13592
Angew. Chem., 2013 , vol. 125, # 51 p. 13833 - 13837,5
参考文献
McArthur, Colin R.; Worster, Paul M.; Okon, Augustine U.
Synthetic Communications, 1983 , vol. 13, # 4 p. 311 - 318
Title/Abstract Full Text Show Details
McArthur, Colin R.; Worster, Paul M.; Okon, Augustine U.
Synthetic Communications, 1983 , vol. 13, # 5 p. 393 - 402
反应条件
dimethylsulfide borane complex in tetrahydrofuran
Ambient temperature;
参考文献
Casara, Patrick; Danzin, Charles; Metcalf, Brian; Jung, Michel
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2201 - 2208
反应条件
thionyl chloride
Yield given;
参考文献
Tolstikov, G. A.; Galin, F. Z.; Lakeev, S. N.; Khalilov, L. M.; Sultanova, V. S.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 3.2 p. 535 - 541
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 3 p. 612 - 620
反应条件
sulfuric acid
T=60°C; 4 h;
参考文献
Coelho, Lucas Cunha Duarte; De Oliveira Cardoso, Marcos Verissimo; Moreira, Diogo Rodrigo Magalhaes; De Moraes Gomes, Paulo Andre Teixeira; Cavalcanti, Suellen Melo Tiburcio; Oliveira, Arsenio Rodrigues; De Oliveira Filho, Gevanio Bezerra; Pessoa De Siqueira, Lucianna Rabelo; De Oliveira Barbosa, Miria; De Oliveira Borba, Elizabeth Fernanda; Da Silva, Teresinha Goncalves; Kaskow, Belinda; Karimi, Mahdad; Abraham, Lawrence J.; Leite, Ana Cristina Lima
MedChemComm, 2014 , vol. 5, # 6 p. 758 - 765
反应条件
1.1: triethylamine / dichloromethane / 0.5 h / Cooling with ice
1.2: 1 h / 20 °C
2.1: dichloromethane / 1 h / 20 °C
View Scheme
参考文献
El-Zahabi, Mohamed A.; Gad, Laila M.; Bamanie, Faida H.; Al-Marzooki, Zohair
Medicinal Chemistry Research, 2012 , vol. 21, # 1 p. 75 - 84
反应条件
1: 80 percent / SOCl2 / 0.83 h / 60 °C
2: 85 percent / H2 / 10percent Pd/BaSO4 / xylene / 10 h / 110 °C
View Scheme
参考文献
Wyslouch, Aleksandra; Lisowski, Marek; Pedyczak, Artur; Siemion, Ignacy Z.
Tetrahedron: Asymmetry, 1992 , vol. 3, # 11 p. 1401 - 1410
