1: ethyl 2-(triphenylsilyl)acetate With potassium hexamethylsilazane in tetrahydrofuran; toluene
T=0°C; Metallation; 0.5 h;
2: benzaldehyde in tetrahydrofuran; toluene
T=-78°C; Condensation; Peterson reaction; 3 h; Further stages. Title compound not separated from byproducts.;
参考文献
Kojima; Inai; Hidaka; Ohkata
Chemical Communications, 2000 , # 18 p. 1795 - 1796
tetrabutyl ammonium fluoride in tetrahydrofuran
to soln. of benzaldehyde and TBAF is added dropwise a soln of ethyl (trimethylgermyl)(trimethylsilyl)acetate in THF at 0°C (N2), stirring for 1 h; mixt. is mixed with ether, washed (aq. NaCl), dried (MgSO4), concd., distd.;
Chikashita, Hidenori; Miyazaki, Makoto; Itoh, Kazuyoshi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 699 - 706