N1-甲基-4-硝基苯-1,2-二胺合成路线 （共 32 条）
反应条件
formic acid; triethylamine in acetonitrile 3 h; Heating;
参考文献
Piersanti, Giovanni; Giorgi, Luca; Bartoccini, Francesca; Tarzia, Giorgio; Minetti, Patrizia; Gallo, Grazia; Giorgi, Fabrizio; Castorina, Massimo; Ghirardi, Orlando; Carminati, Paolo
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 16 p. 2567 - 2571
反应条件
1: in DMF (N,N-dimethyl-formamide); water T=90°C; 3 h; 2: With sodium hydrogencarbonate in DMF (N,N-dimethyl-formamide); water; ethyl acetate
参考文献
METHYLGENE INC.
Patent: WO2005/92899 A1, 2005 ;
Location in patent: Page/Page column 151-152 ;
反应条件
sodium hydroxide; anhydrous sodium hydrogen carbonate in methanol; water
参考文献
Ciba-Geigy Corporation
Patent: US4138568 A1, 1979 ;
反应条件
methylamine in water
参考文献
Boehringer Ingelheim Pharma KG
Patent: US6200976 B1, 2001 ;
US 6200976 B1
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2003/74515 A1, 2003 ;
Location in patent: Page/Page column 59; 102 ;
WO 03/074515 A1
反应条件
1: water; methanol / 0 - 30 °C 2: sodium sulfide; sodium hydrogencarbonate / water; methanol / 25 - 80 °C View Scheme
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara
Patent: WO2012/59932 A1, 2012 ;
WO 2012/059932 A1
参考文献
Katritzky, Alan R.; Rachwal, Stanislaw; Ollmann, Richard
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 4 p. 775 - 780
参考文献
Kehrmann; Messinger
Journal fuer Praktische Chemie (Leipzig), 1892 , vol. <2> 46, p. 574
Chemische Berichte, 1893 , vol. 26, p. 2374
Full Text Show Details
Kehrmann
Chemische Berichte, 1895 , vol. 28, p. 1716
反应条件
hydrochloric acud in N,N-dimethyl-formamide T=20°C; 12 h;
参考文献
Piersanti, Giovanni; Giorgi, Luca; Bartoccini, Francesca; Tarzia, Giorgio; Minetti, Patrizia; Gallo, Grazia; Giorgi, Fabrizio; Castorina, Massimo; Ghirardi, Orlando; Carminati, Paolo
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 16 p. 2567 - 2571
参考文献
Katritzky, Alan R.; Rachwal, Stanislaw; Ollmann, Richard
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 4 p. 775 - 780
