N1-甲基-4-硝基苯-1,2-二胺合成路线 （共 32 条）
反应条件
1: anschliessend Behandeln mit konz. Salzsaeure 2: tin; hydrochloric acid View Scheme
参考文献
Fries
Justus Liebigs Annalen der Chemie, 1927 , vol. 454, p. 204
反应条件
1.1: 35 - 40 °C 1.2: 80 - 85 °C 1.3: 25 - 30 °C 2.1: hydrogen / Raney nickel / methanol / 25 - 30 °C / 4654.46 - 5171.62 Torr 3.1: N-ethyl-N,N-diisopropylamine / water / 25 - 95 °C 4.1: thionyl chloride / dichloromethane / 25 - 60 °C 4.2: 55 - 60 °C View Scheme
反应条件
1: With hydrogenchloride; sodium nitrite in water T=0°C; 3 h; 2: With potassium hydroxide in water
参考文献
METHYLGENE INC.
Patent: WO2005/92899 A1, 2005 ;
Location in patent: Page/Page column 155 ;
反应条件
hydrogenchloride in water 4 h; Reflux;
参考文献
Bai, Yu-Bin; Zhang, An-Ling; Tang, Jiang-Jiang; Gao, Jin-Ming
Journal of Agricultural and Food Chemistry, 2013 , vol. 61, # 11 p. 2789 - 2795
反应条件
1.1: methanol / Reflux 2.1: hydrogen / methanol / 20 °C / 1500.15 Torr 3.1: methanol / 100 °C 3.2: polyphosphoric acid / 0.5 h / 120 °C View Scheme
参考文献
Bella, Maros; Milata, Viktor; Larina, Lyudmila I.
Journal of Heterocyclic Chemistry, 2012 , vol. 49, # 2 p. 293 - 296
反应条件
2: POCl3; PCl5 / 190 °C View Scheme
参考文献
van Romburgh; Huyser
Recueil des Travaux Chimiques des Pays-Bas, 1930 , vol. 49, p. 165,175
反应条件
2: palladium/charcoal; ethanol / Hydrogenation View Scheme
参考文献
Davies et al.
Journal of Pharmacy and Pharmacology, 1951 , vol. 3, p. 420,424
反应条件
1: 56 percent / 0.83 h / 195 - 200 °C 2: 89 percent / HCl / 3.5 h / Heating 3: 57 percent / H2 / Raney-Ni / methanol / 2 h / 45 °C / 760 Torr 4: 43 percent / acetic acid; H2O / 20 °C 5: 58 percent / SOCl2 / CHCl3 / 1.) overnight, 2.) 1 h, 40 deg C View Scheme
参考文献
Werner; Letsch; Ihn; Sohr; Preiss
Die Pharmazie, 1991 , vol. 46, # 2 p. 113 - 114
反应条件
hydrogenchloride; ethanol
参考文献
Brand; Wild
Chemische Berichte, 1923 , vol. 56, p. 110
参考文献
Brand; Wild
Chemische Berichte, 1923 , vol. 56, p. 110
