1: 67 percent / HATU; N-methylmorpholine / acetonitrile / 20 °C 2: 100 percent / cyclohexa-1,4-diene / Pd-C / tetrahydrofuran; propan-2-ol / 2 h / Heating View Scheme

porcine liver esterase in dimethyl sulfoxide T=40°C; pH=5.5; 3 h;