4-(3-氧代丁酰基)哌啶-1-羧酸叔丁酯合成路线 （共 7 条）
反应条件
potassium hydride; acetone in tetrahydrofuran
T=-78 - 20°C;
参考文献
Merck Sharp and Dohme Limited; DIRAT, Olivier; ELLIOTT, Jason, Matthew
Patent: WO2007/3965 A1, 2007 ;
Location in patent: Page/Page column 30-31 ;
WO 2007/003965 A1
反应条件
1: acetone With potassium hydride in tetrahydrofuran
T=20°C;
2: 1-(1,1-dimethylethyl) 4-piperidinedicarboxylate anhydride with 1H-imidazole-1-carboxylic acid in tetrahydrofuran
T=-78 - 20°C;
参考文献
Carling, William Robert; Elliott, Jason Matthew; Mezzogori, Elena; Russell, Michael Geoffrey Neil; Williams, Brian John
Patent: US2009/54440 A1, 2009 ;
Location in patent: Page/Page column 34-35 ;
反应条件
potassium hydride; 1,1'-carbonyldiimidazole in tetrahydrofuran; dichloromethane
T=-78°C;
参考文献
Dirat, Olivier; Clipson, Alex; Elliott, Jason M.; Garrett, Sasha; Brian Jones; Reader, Michael; Shaw, Duncan
Tetrahedron Letters, 2006 , vol. 47, # 11 p. 1729 - 1731
反应条件
sodium hydride in N,N-dimethyl-formamide; mineral oil
T=0 - 20°C; Claisen Condensation; Inert atmosphere;
参考文献
Nimbarte, Vijaykumar D.; Murtuza, Hadianawala; Phaniraj, Sahishna; Shrivastava, Shweta; Naidu; Satheesh Kumar; Atcha, Krishnam Raju
Medicinal Chemistry Research, 2014 , vol. 23, # 5 p. 2178 - 2197
反应条件
1: N,N-dimethyl-formamide / 1 h / 0 °C / |Inert atmosphere
2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Nimbarte, Vijaykumar D.; Murtuza, Hadianawala; Phaniraj, Sahishna; Shrivastava, Shweta; Naidu; Satheesh Kumar; Atcha, Krishnam Raju
Medicinal Chemistry Research, 2014 , vol. 23, # 5 p. 2178 - 2197
反应条件
1: sodium hydroxide / tetrahydrofuran / 0 - 20 °C / |Inert atmosphere
2: N,N-dimethyl-formamide / 1 h / 0 °C / |Inert atmosphere
3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Nimbarte, Vijaykumar D.; Murtuza, Hadianawala; Phaniraj, Sahishna; Shrivastava, Shweta; Naidu; Satheesh Kumar; Atcha, Krishnam Raju
Medicinal Chemistry Research, 2014 , vol. 23, # 5 p. 2178 - 2197
反应条件
1: sodium hydroxide / tetrahydrofuran / 0 - 20 °C / |Inert atmosphere
2: N,N-dimethyl-formamide / 1 h / 0 °C / |Inert atmosphere
3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Nimbarte, Vijaykumar D.; Murtuza, Hadianawala; Phaniraj, Sahishna; Shrivastava, Shweta; Naidu; Satheesh Kumar; Atcha, Krishnam Raju
Medicinal Chemistry Research, 2014 , vol. 23, # 5 p. 2178 - 2197
