1-氯-4-(2,2-二乙氧基乙氧基)苯合成路线 （共 4 条）
反应条件
PPA in toluene 3 h; Heating / reflux;
参考文献
BIOENERGENIX; MCCALL, John M.; ROMERO, Donna L.; KELLY, Robert C.
Patent: WO2012/119046 A2, 2012 ;
Location in patent: Page/Page column 68 ;
反应条件
1: 4-chloro-phenol With sodium hydride in N,N-dimethyl-formamide
T=0°C;
2: 2-bromoacetaldehyde diethyl acetal in N,N-dimethyl-formamide
T=120°C;
参考文献
BIOENERGENIX; MCCALL, John M.; ROMERO, Donna L.; KELLY, Robert C.
Patent: WO2012/119046 A2, 2012 ;
Location in patent: Page/Page column 68 ;
反应条件
potassium hydroxide in water
参考文献
Pfizer Inc.
Patent: US4282242 A1, 1981 ;
反应条件
ethanol; sodium ethanolate
参考文献
Julia; Tchernoff
Bulletin de la Societe Chimique de France, 1953 , p. 479,481, 483
Full Text Show Details
Dow Chem. Co.
Patent: US2553555 , 1950 ;
