3,5-二甲基-4-羟基苯甲腈合成路线 （共 25 条）
反应条件
1: PBr3 2: CuSO4+5H2O; pyridine View Scheme
参考文献
Bielig; Luetzel
Justus Liebigs Annalen der Chemie, 1957 , vol. 608, p. 140,156
反应条件
in 1,2-dichloro-benzene 2 h; Reflux;
参考文献
Hou, Shili; Li, Xinyao; Xu, Jiaxi
Journal of Organic Chemistry, 2012 , vol. 77, # 23 p. 10856 - 10869
反应条件
1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 2 h / 70 °C / Large scale reaction 2: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 2 h / 0 - 5 °C / Large scale reaction View Scheme
参考文献
Joshi, Shashikant; Maikap, Golak C.; Titirmare, Shyam; Chaudhari, Ashok; Gurjar, Mukund K.
Organic Process Research and Development, 2010 , vol. 14, # 3 p. 657 - 660
参考文献
Thiele; Eichwede
Justus Liebigs Annalen der Chemie, 1900 , vol. 311, p. 366 Anm.
反应条件
1: With borane-THF in tetrahydrofuran 16 h; Heating / reflux; 2: With hydrogenchloride in tetrahydrofuran; water 0.5 h; Heating / reflux;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2006/10544 A2, 2006 ;
Location in patent: Page/Page column 40-41 ;
WO 2006/010544 A2
反应条件
1: 93.2 percent / K2CO3 / acetone / 18 h / Heating 2: 62 percent / NaN3, NH4Cl / dimethylformamide / 24 h / 110 °C 3: 67 percent / K2CO3 / acetonitrile / 1 h / Heating 4: 96 percent / BBr3 / CH2Cl2 View Scheme
参考文献
Sterling Winthrop Inc.
Patent: US5364865 A1, 1994 ;
反应条件
(i) (hydrolysis), (ii) /BRN= 1098229/, H2SO4; Multistep reaction;
参考文献
Fujio,M. et al.
Bulletin of the Chemical Society of Japan, 1975 , vol. 48, p. 2127 - 2133
反应条件
potassium carbonate; potassium iodide in various solvent(s) T=65°C; 24 h;
参考文献
Diana; Volkots; Nitz; Bailey; Long; Vescio; Aldous; Pevear; Dutko
Journal of Medicinal Chemistry, 1994 , vol. 37, # 15 p. 2421 - 2436
参考文献
Sterling Winthrop Inc.
Patent: US5464848 A1, 1995 ;
US 5464848 A
反应条件
potassium carbonate in acetone 18 h; Heating;
参考文献
Diana, Guy D.; Cutcliffe, David; Volkots, Deborah L.; Mallamo, John P.; Bailey, Thomas R.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3240 - 3250
