6,7-二甲氧基-1,2,3,4-四氢-异喹啉-1-羧酸乙酯合成路线 （共 6 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 3 h; Heating;
参考文献
Zalan, Zita; Martinek, Tamas A.; Lazar, Laszlo; Sillanpaeae, Reijo; Fueloep, Ferenc
Tetrahedron, 2006 , vol. 62, # 12 p. 2883 - 2891
反应条件
hydrogen; platinum on activated charcoal in ethanol
T=20°C; P=760 Torr; 6 h;
参考文献
Zalan, Zita; Martinek, Tamas A.; Lazar, Laszlo; Sillanpaeae, Reijo; Fueloep, Ferenc
Tetrahedron, 2006 , vol. 62, # 12 p. 2883 - 2891
反应条件
1: molecular sieves 4 Angstroem / CH2Cl2 / 18 h / 20 °C
2: 34 percent / gold(III) chloride; silver(I) trifluoromethanesulfonate / 1,2-dichloro-ethane / 24 h / 80 °C
View Scheme
参考文献
Youn, So Won
Journal of Organic Chemistry, 2006 , vol. 71, # 6 p. 2521 - 2523
反应条件
ethanol; toluene; trichlorophosphate
T=120°C; Hydrieren des Reaktionsprodukts an Platin in Methanol;
参考文献
Gruessner et al.
Helvetica Chimica Acta, 1959 , vol. 42, p. 2431,2436
反应条件
2: 2 N aq. NaOH / dioxane / 65 °C
3: 95 percent / DCC, air / CH2Cl2 / 18 h / Ambient temperature
4: 95 percent / 6 N aq. HCl / dioxane / 0.5 h / Heating
View Scheme
参考文献
Kawase, Masami
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 8 p. 1248 - 1253
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran
0.75 h;
参考文献
Koelzer, Michael; Weitzel, Kerstin; Goeringer, H. Ulrich; Thines, Eckhard; Opatz, Till
ChemMedChem, 2010 , vol. 5, # 9 p. 1456 - 1464
