5-氯-2-硝基苯甲酰氯合成路线 （共 24 条）
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 17, p. 596 - 604
反应条件
thionyl chloride
Heating / reflux;
参考文献
Aventis Pharma Deutschland GmbH
Patent: US6335334 B1, 2002 ;
Location in patent: Page column 30 ;
反应条件
phosphorus pentachloride in tetrachloromethane; cyclohexane
参考文献
The Dow Chemical Company
Patent: US4419357 A1, 1983 ;
反应条件
zinc in toluene
T=20°C; 2 h;
参考文献
Beccalli, Egle M.; Broggini, Gianluigi; Paladino, Giuseppe; Zoni, Caterina
Tetrahedron, 2005 , vol. 61, # 1 p. 61 - 68
反应条件
1: 72 percent / zinc powder / toluene / 2 h / 20 °C
2: 90 percent / NaH / tetrahydrofuran / 12 h / 30 - 35 °C
View Scheme
参考文献
Beccalli, Egle M.; Broggini, Gianluigi; Paladino, Giuseppe; Zoni, Caterina
Tetrahedron, 2005 , vol. 61, # 1 p. 61 - 68
反应条件
1: 72 percent / zinc powder / toluene / 2 h / 20 °C
2: 82 percent / NaH / tetrahydrofuran / 12 h / 30 - 35 °C
View Scheme
参考文献
Beccalli, Egle M.; Broggini, Gianluigi; Paladino, Giuseppe; Zoni, Caterina
Tetrahedron, 2005 , vol. 61, # 1 p. 61 - 68
反应条件
1: 72 percent / zinc powder / toluene / 2 h / 20 °C
2: 90 percent / NaH / tetrahydrofuran / 12 h / 30 - 35 °C
3: 98 percent / AcOH; Fe dust / ethanol / 5 h / Heating
View Scheme
参考文献
Beccalli, Egle M.; Broggini, Gianluigi; Paladino, Giuseppe; Zoni, Caterina
Tetrahedron, 2005 , vol. 61, # 1 p. 61 - 68
反应条件
1: 72 percent / zinc powder / toluene / 2 h / 20 °C
2: 82 percent / NaH / tetrahydrofuran / 12 h / 30 - 35 °C
3: 66 percent / AcOH; Fe dust / ethanol / 5 h / Heating
View Scheme
参考文献
Beccalli, Egle M.; Broggini, Gianluigi; Paladino, Giuseppe; Zoni, Caterina
Tetrahedron, 2005 , vol. 61, # 1 p. 61 - 68
反应条件
1: NH3(g) / benzene / 20 °C
2: dimethylformamide / 3 h / 110 °C
View Scheme
参考文献
Hour; Lee; Chen; Zhao
British Journal of Pharmacology, 2013 , vol. 169, # 7 p. 1574 - 1586
参考文献
Morera, Ludovica; Labar, Geoffray; Ortar, Giorgio; Lambert, Didier M.
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 21 p. 6260 - 6275
