4-氯-4'-羟基二苯甲酮合成路线 （共 30 条）
反应条件
1: aqueous NaOH 2: AlCl3 View Scheme
参考文献
Malik; Saharia
Journal of Scientific and Industrial Research, 1956 , vol. 15 B, p. 633
反应条件
hydrogen bromide; acetic acid
参考文献
Montagne
Recueil des Travaux Chimiques des Pays-Bas, 1920 , vol. 39, p. 345
Recueil des Travaux Chimiques des Pays-Bas, 1922 , vol. 41, p. 717
反应条件
1: aluminium chloride; carbon disulfide 2: glacial acetic acid; hydrobromic acid View Scheme
参考文献
Montagne
Recueil des Travaux Chimiques des Pays-Bas, 1920 , vol. 39, p. 345
Recueil des Travaux Chimiques des Pays-Bas, 1922 , vol. 41, p. 717
反应条件
aluminium trichloride
参考文献
Malik; Saharia
Journal of Scientific and Industrial Research, 1956 , vol. 15 B, p. 633
参考文献
Nakazawa; Baba
Yakugaku Zasshi, 1955 , vol. 75, p. 378,380
Chem.Abstr., 1956 , p. 2510
反应条件
1: NaOH 2: aq. H2SO4 View Scheme
参考文献
FR2300552DE2605382 , ;
Chem.Abstr., , vol. 85, # 192382
反应条件
potassium hydrogencarbonate in isopropyl alcohol 48 h; Heating / reflux; Purification / work up;
参考文献
EP1837327 A1, ;
Page/Page column 4 ;
反应条件
(i) KOH, (ii) /BRN= 1731042/, (iii) /BRN= 635639/, H2SO4, benzene; Multistep reaction;
参考文献
Arzneimittel-Forschung, , vol. 29, # 5 p. 711 - 720
反应条件
1: (4-chlorophenyl)(4-hydroxyphenyl)methanone; acetone With sodium hydroxide 2 h; Heating / reflux; 2: chloroform in acetone 8 h; Heating / reflux;
参考文献
SIGNATURE PHARMACEUTICALS, LLC
Patent: WO2005/46575 A2, 2005 ;
Location in patent: Page/Page column 176-177 ;
反应条件
1: (4-chlorophenyl)(4-hydroxyphenyl)methanone With sodium hydroxide in butanone T=50°C; 1 h; 2: 2-bromo-2-methyl-propionic acid in butanone T=50°C; 16 h;
参考文献
Davis, Roman D.; Fitzgerald, Russ N.; Guo, Jiasheng
Synthesis, 2004 , # 12 p. 1959 - 1962
