4-氯-4'-羟基二苯甲酮合成路线 （共 30 条）
反应条件
1: ethyl 2-bromo-2-methyl propionate; (4-chlorophenyl)(4-hydroxyphenyl)methanone With potassium carbonate T=145°C; 3 h; 2: N,N,N-trimethyl-2-hydroxyethyl-ammonium hydroxide in propan-1-ol; water 3 h; Heating / reflux;
参考文献
US2008/275270 A1, ;
Page/Page column 3 ;
反应条件
1: BrCMe2CO2iPr; (4-chlorophenyl)(4-hydroxyphenyl)methanone With potassium carbonate T=145 - 155°C; 3 - 6 h; 2: N,N,N-trimethyl-2-hydroxyethyl-ammonium hydroxide in propan-1-ol; water 3 h; Heating / reflux; Product distribution / selectivity;
参考文献
US2008/275270 A1, ;
Page/Page column 3 ;
反应条件
1: NaOH 2: aq. H2SO4 3: KBH4 View Scheme
参考文献
Labor. Fournier
Patent: FR2300552DE2605382 , 19761976 ;
Chem.Abstr., 1976 , vol. 85, # 192382
反应条件
potassium carbonate in acetone Heating;
参考文献
Kumar, Rakesh; Ramachandran, Uma; Raichur, Suryaprakash; Chakrabarti, Ranjan; Jain, Rahul
European Journal of Medicinal Chemistry, 2007 , vol. 42, # 4 p. 503 - 510
反应条件
potassium carbonate in acetone 4 h; Heating;
参考文献
Massolini; Carmellino; Baruffini
Farmaco, Edizione Scientifica, 1986 , vol. 41, # 5 p. 381 - 387
反应条件
1: With potassium hydroxide; triethylamine in water; N,N-dimethyl-formamide T=100°C; 2: 1,1,2,2-tetrafluoroethylene; (4-chlorophenyl)(4-hydroxyphenyl)methanone T=110°C; 0.5 h;
参考文献
Boeger, Manfred; Duerr, Dieter; Gsell, Laurenz; Hall, Roger G.; Karrer, Friedrich; Kristiansen, Odd; Maienfisch, Peter; Pascual, Alfons; Rindlisbacher, Alfred
Pest Management Science, 2001 , vol. 57, # 2 p. 191 - 202
反应条件
potassium carbonate in acetone
4 h; Heating;
参考文献
Massolini; Carmellino; Baruffini
Farmaco, Edizione Scientifica, 1986 , vol. 41, # 5 p. 381 - 387
反应条件
potassium carbonate in acetone
4 h; Heating;
参考文献
Massolini; Carmellino; Baruffini
Farmaco, Edizione Scientifica, 1986 , vol. 41, # 5 p. 381 - 387
反应条件
sodium; hydrazine hydrate; diethylene glycol
参考文献
G.D. SEARLE and CO.
Patent: EP1221441 A2, 2002 ;
Location in patent: Page 55 ;
反应条件
hydrogenchloride; potassium carbonate
1) acetone, reflux, 4 h; Multistep reaction;
参考文献
Massolini; Carmellino; Borgna
Farmaco, 1990 , vol. 45, # 2 p. 263 - 268
