丙酮基膦酸二甲酯合成路线

参考文献

ALLERGAN, INC.
Patent: US2009/275627 A1, 2009 ;
Location in patent: Page/Page column 9 ;
US 20090275627 A1

4202-14-6丙酮基膦酸二甲酯

757-54-0烯丙基磷酸二甲酯

参考文献

Ulman,A.; Sprecher,M.
Journal of Organic Chemistry, 1979 , vol. 44, p. 3703 - 3707

4202-14-6丙酮基膦酸二甲酯+

66-25-1正己醛

14309-57-03-壬烯-2-酮

参考文献

Jaxa-Chamiec, Albert A.; Sammes, Peter G.; Kennewell, Peter D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 170 - 175

4202-14-6丙酮基膦酸二甲酯+

3218-36-8对苯基苯甲醛

32979-83-2

参考文献

Sato; Ogiso; Noguchi; Mitsui; Kaneko; Shimada
Chemical and pharmaceutical bulletin, 1980 , vol. 28, # 5 p. 1509 - 1525

4202-14-6丙酮基膦酸二甲酯+

69610-41-9(S)-N-Boc-吡咯烷-2-甲醛 N-(叔丁氧羰基)-L-脯氨醛

130418-90-5(2R)-2-乙炔-1-吡咯烷羧酸-1,1-二甲基乙酯

参考文献

MEDIVIR AB; AYESA, Susana; BELDA, Oscar; BJÖRKLUND, Catarina; NILSSON, Magnus; RUSSO, Francesco; SAHLBERG, Christer; WIKTELIUS, Daniel
Patent: WO2013/95275 A1, 2013 ;
Location in patent: Page/Page column 41; 42 ;

4202-14-6丙酮基膦酸二甲酯+

69610-41-9(S)-N-Boc-吡咯烷-2-甲醛 N-(叔丁氧羰基)-L-脯氨醛

130418-90-5(2R)-2-乙炔-1-吡咯烷羧酸-1,1-二甲基乙酯

参考文献

MEDIVIR AB; AYESA, Susana; BELDA, Oscar; BJÖRKLUND, Catarina; NILSSON, Magnus; RUSSO, Francesco; SAHLBERG, Christer; WIKTELIUS, Daniel
Patent: WO2013/95275 A1, 2013 ;
Location in patent: Page/Page column 41; 42 ;

4202-14-6丙酮基膦酸二甲酯+

95715-87-0(R)-(+)-3-Boc-2,2-二甲基噁唑啉-4-甲醛

173065-16-2(4S)-4-乙炔基-2,2-二甲基-1,3-噁唑烷-3-甲酸叔丁酯

参考文献

Spangenberg, Thomas; Schoenfelder, Angele; Breit, Bernhard; Mann, Andre
European Journal of Organic Chemistry, 2010 , # 31 p. 6005 - 6018

4202-14-6丙酮基膦酸二甲酯+

91103-36-5

162107-49-5(R)-(1-羟基甲基-3-丁炔基)-氨基甲酸叔丁酯

参考文献

CORTEX PHARMACEUTICALS, INC.
Patent: WO2009/38752 A2, 2009 ;
Location in patent: Page/Page column 48-50 ;

4202-14-6丙酮基膦酸二甲酯+

4361-28-8环己烷丙醛

141345-08-6

参考文献

METHYLGENE INC.; Raeppel, Franck; Raeppel, Stephane; Vaisburg, Arkadii
Patent: US2014/81017 A1, 2014 ;
Location in patent: Paragraph 0352 ;

4202-14-6丙酮基膦酸二甲酯+

109608-77-7(1,1-二甲基-2-氧代乙基)氨基甲酸叔丁酯

113486-06-9

参考文献

Rajagopal, Basker; Chen, Ying-Yu; Chen, Chun-Chi; Liu, Xuan-Yu; Wang, Huei-Ren; Lin, Po-Chiao
Journal of Organic Chemistry, 2014 , vol. 79, # 3 p. 1254 - 1264