2-氨基-3-苯甲酰基-4,5-二甲基噻吩合成路线 （共 9 条）
反应条件
morpholine; sulfur in ethanol
T=70°C;
参考文献
F.HOFFMANN-LA ROCHE AG
Patent: WO2006/63732 A1, 2006 ;
Location in patent: Page/Page column 30 ;
反应条件
potassium hydroxide in methanol
0.75 h; Heating;
参考文献
Tranberg, C. Elisabet; Zickgraf, Andrea; Giunta, Brian N.; Luetjens, Henning; Figler, Heidi; Murphree, Lauren J.; Falke, Ruediger; Fleischer, Holger; Linden, Joel; Scammells, Peter J.; Olsson, Ray A.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 2 p. 382 - 389
反应条件
hydrogen sulfide; hydrogen in ethanol
参考文献
Medco Research, Inc
Patent: US6323214 B1, 2001 ;
反应条件
1: 79 percent / tin(IV) chloride / benzene / 2 h / -5 - 20 °C
2: 85 percent / hydroxylamine hydrochloride; barium carbonate / ethanol / 8 h / Heating
3: 32 percent / PCl5 / diethyl ether / 0.75 h / 0 - 20 °C
4: 82 percent / tin(IV) chloride / 1,2-dichloro-ethane / 10.5 h / Heating
5: 98 percent / aq. KOH / methanol / 0.75 h / Heating
View Scheme
参考文献
Tranberg, C. Elisabet; Zickgraf, Andrea; Giunta, Brian N.; Luetjens, Henning; Figler, Heidi; Murphree, Lauren J.; Falke, Ruediger; Fleischer, Holger; Linden, Joel; Scammells, Peter J.; Olsson, Ray A.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 2 p. 382 - 389
反应条件
1.1: hydrazine hydrate; ethylene glycol / 130 - 160 °C
1.2: 77 percent / KOH / 0.25 h / 90 - 100 °C
2.1: 79 percent / tin(IV) chloride / benzene / 2 h / -5 - 20 °C
3.1: 85 percent / hydroxylamine hydrochloride; barium carbonate / ethanol / 8 h / Heating
4.1: 32 percent / PCl5 / diethyl ether / 0.75 h / 0 - 20 °C
5.1: 82 percent / tin(IV) chloride / 1,2-dichloro-ethane / 10.5 h / Heating
6.1: 98 percent / aq. KOH / methanol / 0.75 h / Heating
View Scheme
参考文献
Tranberg, C. Elisabet; Zickgraf, Andrea; Giunta, Brian N.; Luetjens, Henning; Figler, Heidi; Murphree, Lauren J.; Falke, Ruediger; Fleischer, Holger; Linden, Joel; Scammells, Peter J.; Olsson, Ray A.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 2 p. 382 - 389
反应条件
1: 85 percent / hydroxylamine hydrochloride; barium carbonate / ethanol / 8 h / Heating
2: 32 percent / PCl5 / diethyl ether / 0.75 h / 0 - 20 °C
3: 82 percent / tin(IV) chloride / 1,2-dichloro-ethane / 10.5 h / Heating
4: 98 percent / aq. KOH / methanol / 0.75 h / Heating
View Scheme
参考文献
Tranberg, C. Elisabet; Zickgraf, Andrea; Giunta, Brian N.; Luetjens, Henning; Figler, Heidi; Murphree, Lauren J.; Falke, Ruediger; Fleischer, Holger; Linden, Joel; Scammells, Peter J.; Olsson, Ray A.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 2 p. 382 - 389
反应条件
1: 82 percent / tin(IV) chloride / 1,2-dichloro-ethane / 10.5 h / Heating
2: 98 percent / aq. KOH / methanol / 0.75 h / Heating
View Scheme
参考文献
Tranberg, C. Elisabet; Zickgraf, Andrea; Giunta, Brian N.; Luetjens, Henning; Figler, Heidi; Murphree, Lauren J.; Falke, Ruediger; Fleischer, Holger; Linden, Joel; Scammells, Peter J.; Olsson, Ray A.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 2 p. 382 - 389
反应条件
1: 82 percent / tin(IV) chloride / 1,2-dichloro-ethane / 10.5 h / Heating
2: 98 percent / aq. KOH / methanol / 0.75 h / Heating
View Scheme
参考文献
Tranberg, C. Elisabet; Zickgraf, Andrea; Giunta, Brian N.; Luetjens, Henning; Figler, Heidi; Murphree, Lauren J.; Falke, Ruediger; Fleischer, Holger; Linden, Joel; Scammells, Peter J.; Olsson, Ray A.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 2 p. 382 - 389
反应条件
1: 32 percent / PCl5 / diethyl ether / 0.75 h / 0 - 20 °C
2: 82 percent / tin(IV) chloride / 1,2-dichloro-ethane / 10.5 h / Heating
3: 98 percent / aq. KOH / methanol / 0.75 h / Heating
View Scheme
参考文献
Tranberg, C. Elisabet; Zickgraf, Andrea; Giunta, Brian N.; Luetjens, Henning; Figler, Heidi; Murphree, Lauren J.; Falke, Ruediger; Fleischer, Holger; Linden, Joel; Scammells, Peter J.; Olsson, Ray A.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 2 p. 382 - 389
