1-(2-羟基乙基)-4-硝基-1H-吡唑合成路线 （共 3 条）
反应条件
potassium carbonate in acetonitrile
T=60°C; 6 h;
参考文献
XCOVERY, INC.
Patent: WO2009/154769 A1, 2009 ;
Location in patent: Page/Page column 41 ;
WO 2009/154769 A1
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
T=20°C; 3 h;
参考文献
F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BAKER-GLENN, Charles; CHAN, Bryan K.; DOTSON, Jennafer; ESTRADA, Anthony; HEFFRON, Timothy; LYSSIKATOS, Joseph; SWEENEY, Zachary Kevin
Patent: WO2013/164323 A1, 2013 ;
Location in patent: Page/Page column 55; 56 ;
反应条件
hydrogen; palladium 10 on activated carbon in ethanol
P=760.051 Torr; 0.5 h;
参考文献
CELLZOME LIMITED; OXENFORD, Sally; HOBSON, Andrew; OLIVER, Kathryn; RATCLIFFE, Andrew; RAMSDEN, Nigel
Patent: WO2013/17479 A1, 2013 ;
Location in patent: Page/Page column 48 ;
WO 2013/017479 A1
