(S)-(-)-3-羟基-5-氧代-1-环戊烯基-1-己酸甲酯合成路线 （共 5 条）
反应条件
216 h; Ambient temperatureporcine pancreatic lipase;
参考文献
Rodriguez, Ana; Nomen, Miguel; Spur, Bernd Werner; Godfroid, Jean-Jacques
European Journal of Organic Chemistry, 1999 , # 10 p. 2655 - 2662
反应条件
1: Et3N / CH2Cl2 / -10 °C 2: guanidine / methanol / 0.25 h / 0 °C View Scheme
参考文献
Rodriguez, Ana; Nomen, Miguel; Spur, Bernd Werner; Godfroid, Jean-Jacques
European Journal of Organic Chemistry, 1999 , # 10 p. 2655 - 2662
反应条件
1.1: Et3N / CH2Cl2 / -10 °C 2.1: guanidine / methanol / 0.25 h / 0 °C 3.1: 88 percent / Et3N / tetrahydrofuran / 20 °C 4.1: n-BuLi; CuCN; MeLi / diethyl ether / 3.08 h / -78 - 0 °C 4.2: diethyl ether; hexane / 0.33 h / -78 °C 5.1: pyridinium p-toluenesulfonate / acetone; H2O / 4 h / 20 °C 6.1: 89 percent / porcine pancreatic lipase; NaCl; CaCl2 / H2O; tetrahydrofuran / 0.5 h / Enzymatic reaction; pH 7.1 View Scheme
参考文献
Rodriguez, Ana; Nomen, Miguel; Spur, Bernd Werner; Godfroid, Jean-Jacques
European Journal of Organic Chemistry, 1999 , # 10 p. 2655 - 2662
反应条件
1H-imidazole; triethylamine in N,N-dimethyl-formamide
参考文献
Rodriguez, Ana R.; Spur, Bernd W.
Tetrahedron Letters, 2002 , vol. 43, # 26 p. 4575 - 4579
反应条件
1: Et3N / CH2Cl2 / -10 °C 2: guanidine / methanol / 0.25 h / 0 °C 3: 88 percent / Et3N / tetrahydrofuran / 20 °C View Scheme
参考文献
Rodriguez, Ana; Nomen, Miguel; Spur, Bernd Werner; Godfroid, Jean-Jacques
European Journal of Organic Chemistry, 1999 , # 10 p. 2655 - 2662
