3-(甲基氨基)-1-丙醇合成路线 （共 24 条）
参考文献
WAKAMOTO PHARMACEUTICAL CO., LTD.
Patent: WO2006/51851 A1, 2006 ;
Location in patent: Page/Page column 77-78 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 17.3333 h; RefluxInert atmosphere; 2: With sodium sulfate decahydrate in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
Trapp, Sean G.; Leadbetter, Michael R.; Long, Daniel D.; Jiang, Lan; Axt, Sabine
Patent: US2009/247627 A1, 2009 ;
Location in patent: Page/Page column 17 ;
US 20090247627 A1
反应条件
palladium 10 on activated carbon; hydrogen in ethanol T=60°C; P=15201 Torr; 4 h; Autoclave;
参考文献
Maslowska-Lipowicz, Iwona; Walczynski, Krzysztof
Chemical Biology and Drug Design, 2014 , vol. 83, # 1 p. 106 - 118
反应条件
1: With methylamine in water 72 h; Heating / reflux; 2: With potassium carbonate in water T=20°C; Product distribution / selectivity;
参考文献
Wyeth
Patent: US2005/124806 A1, 2005 ;
Location in patent: Page/Page column 4 ;
反应条件
Cs-P-Si T=300°C; P=61504.9 Torr;
参考文献
Oku, Tomoharu; Arita, Yoshitaka; Tsuneki, Hideaki; Ikariya, Takao
Journal of the American Chemical Society, 2004 , vol. 126, # 23 p. 7368 - 7377
反应条件
Cs-P-Si mixed-oxide T=300°C; P=61504.9 Torr; Title compound not separated from byproducts;
参考文献
Oku, Tomoharu; Ikariya, Takao
Angewandte Chemie - International Edition, 2002 , vol. 41, # 18 p. 3476 - 3479
参考文献
Goldberg; Whitmore
Journal of the American Chemical Society, 1937 , vol. 59, p. 2280
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Katritzky, Alan R.; Baker, Victor J.; Brito-Palma, Fernando M. S.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1980 , p. 1739 - 1745
反应条件
in ethanol T=20°C; 144 h;
参考文献
Sheldrake, Peter; Tyrrell, Elizabeth; Mintias, Shirin; Shahid, Imran
Synthetic Communications, 2003 , vol. 33, # 13 p. 2263 - 2268
反应条件
hydrogenchloride 17 h;
参考文献
Kabalka; Li; Pace
Synthetic Communications, 1995 , vol. 25, # 14 p. 2135 - 2143
