(9ci)-1-(2-丙炔)-1H-苯并咪唑合成路线 （共 4 条）
反应条件
1: 1H-benzo[d]imidazole With potassium tert-butylate in N,N-dimethyl-formamide
T=0 - 20°C; 1 h;
2: alpha-bromoacetonitrile in N,N-dimethyl-formamide
T=20°C; 3 h;
参考文献
N.V. ORGANON
Patent: WO2007/54474 A1, 2007 ;
Location in patent: Page/Page column 8 ;
WO 2007/054474 A1
反应条件
sodium hydroxide; tetrabutylammomium bromide in benzene
4 h; Ambient temperature;
参考文献
Broggini, Gianluigi; Bruche, Luca; Zecchi, Gaetano; Pilati, Tullio
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , p. 533 - 539
反应条件
ammonia in methanol
T=120°C;
参考文献
Bognar, Balazs; Kalai, Tamas; Hideg, Kalman
Synthesis, 2008 , # 15 art. no. P04808SS, p. 2439 - 2445
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=50°C;
参考文献
Ehrhardt, Heinz; Mildenberger, Hilmar
Liebigs Annalen der Chemie, 1982 , # 5 p. 989 - 993
