反应条件
1: H2; H2SO4 / PtO2 / methanol / 18 h / 20 °C
2: HNO3; AcOH / 2 h / 20 °C
3: Et3N; H2O / tetrahydrofuran / 18 h / 20 °C
4: K2CO3 / acetone / 18 h / Heating
5: H2 / Pd/C / 18 h / 50 °C / 2250.18 Torr
6: HCl / diethyl ether; propan-2-ol / 18 h / Heating
7: i-Pr2NEt / propan-2-ol / 48 h / Heating
View Scheme
参考文献
Atkinson, Peter J.; Bromidge, Steven M.; Duxon, Mark S.; Gaster, Laramie M.; Hadley, Michael S.; Hammond, Beverley; Johnson, Christopher N.; Middlemiss, Derek N.; North, Stephanie E.; Price, Gary W.; Rami, Harshad K.; Riley, Graham J.; Scott, Claire M.; Shaw, Tracey E.; Starr, Kathryn R.; Stemp, Geoffrey; Thewlis, Kevin M.; Thomas, David R.; Thompson, Mervyn; Vong, Antonio K.K.; Watson, Jeannette M.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 3 p. 737 - 741