8-氯-2-甲基-5-羟基喹啉合成路线 （共 2 条）
反应条件
1: With hydrogen bromide in water
20 h; Heating / reflux;
2: With sodium hydrogencarbonate in water
参考文献
GLAXO GROUP LIMITED
Patent: WO2004/46124 A1, 2004 ;
Location in patent: Page 45 ;
WO 2004/046124 A1
反应条件
1: aq. HCl / Heating
2: BBr3 / CH2Cl2
View Scheme
参考文献
Lovell, Peter J.; Blaney, Frank E.; Goodacre, Caroline J.; Scott, Claire M.; Smith, Paul W.; Starr, Kathryn R.; Thewlis, Kevin M.; Vong, Antonio K.K.; Ward, Simon E.; Watson, Jeannette M.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 4 p. 1033 - 1036
