2-硝基-3-氯苯甲酸甲酯合成路线 （共 9 条）
反应条件
iron; acetic acid in ethanol T=20°C; 2 h; Heating / reflux;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/259850 A1, 2007 ;
Location in patent: Page/Page column 99 ;
US 20070259850 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=40°C; 1 h;
参考文献
STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY
Patent: WO2008/156656 A2, 2008 ;
Location in patent: Page/Page column 44; 181 ;
反应条件
1: With Na2WO4·2H2O; sulfuric acid; dihydrogen peroxide in methanol; water
T=40°C; pH=0.5; 2 h;
2: With potassium hydroxide in methanol; water; toluene
T=20 - 30°C; 12 h; Reagent/catalystTemperaturepH-valueSolvent;
参考文献
IHARA CHEMICAL INDUSTRY CO., LTD.; Tani, Shinki; Yadomatsu, Nami; Ikumi, Akiko; Hirano, Yuuki; Ido, Takuya
Patent: US2014/163256 A1, 2014 ;
Location in patent: Paragraph 0163-0164 ;
反应条件
in methanol; hexanes; acetonitrile
T=0°C; 0.5 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/259850 A1, 2007 ;
Location in patent: Page/Page column 98-99 ;
US 20070259850 A1
反应条件
potassium carbonate in acetone
Esterification; 0.5 h; Heating;
参考文献
Kondo, Kazumi; Ogawa, Hidenori; Yamashita, Hiroshi; Miyamoto, Hisashi; Tanaka, Michinori; Nakaya, Kenji; Kitano, Kazuyoshi; Yamamura, Yoshitaka; Nakamura, Shigeki; Onogawa, Toshiyuki; Mori, Toyoki; Tominaga, Michiaki
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 8 p. 1743 - 1754
反应条件
in diethyl ether
Inert atmosphere;
参考文献
Li, Yang; Soe, Chan Myae Myae; Wilson, Justin J.; Tuang, Suan Lian; Apfel, Ulf-Peter; Lippard, Stephen J.
European Journal of Inorganic Chemistry, 2013 , # 12 p. 2011 - 2019
反应条件
1.1: copper(l) chloride; ammonia / methanol / 20 h / 130 °C / 22801.5 Torr / |Autoclave
2.1: tetrabutylammomium bromide; potassium carbonate / toluene / 1 h / 80 °C
3.1: Na2WO4·2H2O; sulfuric acid; dihydrogen peroxide / methanol; water / 2 h / 40 °C / pH 0.5
3.2: 12 h / 20 - 30 °C
View Scheme
参考文献
IHARA CHEMICAL INDUSTRY CO., LTD.; Tani, Shinki; Yadomatsu, Nami; Ikumi, Akiko; Hirano, Yuuki; Ido, Takuya
Patent: US2014/163256 A1, 2014 ;
反应条件
sulfuric acid
Reflux;
参考文献
Hansen, Finn K.; Khankischpur, Mehdi; Tolaymat, Ibrahim; Mesaros, Renata; Dannhardt, Gerd; Geffken, Detlef
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 5031 - 5034
反应条件
1.1: SnCl2*2H2O; conc. HCl / ethanol / 20 °C
2.1: 23 percent / pyridine / 20 °C
3.1: 100 percent / K2CO3 / dimethylformamide / 4 h / 120 °C
4.1: t-BuOK / toluene / 0.5 h / Heating
4.2: 59 percent / conc. HCl / acetic acid / 5 h / Heating
5.1: 84 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C
View Scheme
参考文献
Kondo, Kazumi; Ogawa, Hidenori; Yamashita, Hiroshi; Miyamoto, Hisashi; Tanaka, Michinori; Nakaya, Kenji; Kitano, Kazuyoshi; Yamamura, Yoshitaka; Nakamura, Shigeki; Onogawa, Toshiyuki; Mori, Toyoki; Tominaga, Michiaki
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 8 p. 1743 - 1754
