5-氯-1-甲基-4-硝基-1H-吡唑合成路线 （共 2 条）
反应条件
1: With lithium hexamethyldisilazane in tetrahydrofuran
T=-78°C; 0.833333 h;
2: With 1,2,2-trichloro-1,1,2-trichloro-ethane in tetrahydrofuran
T=-78 - -45°C; 2.75 h;
参考文献
GENENTECH, INC.; Hodges, Alastair James; Matteucci, Mizio; Sharpe, Andrew; Sun, Minghua; Wang, Xiaojing; Tsui, Vickie H.
Patent: US2013/79321 A1, 2013 ;
Location in patent: Paragraph 0177; 0178; 0179 ;
反应条件
sodium hydroxide; ammonium chloride; dimethyl sulfate; lithium hexamethyldisilazane in tetrahydrofuran; ethyl acetate
参考文献
Genentech, Inc.; Burch, Jason; Sun, Minghua; Wang, Xiaojing; Blackaby, Wesley; Hodges, Alastair James; Sharpe, Andrew
Patent: US2014/88117 A1, 2014 ;
Location in patent: Page/Page column ;
