1-(叔丁氧基羰基)-2-苯肼合成路线 （共 21 条）
反应条件
1.1: pyridine; N-bromosuccinmide / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere 2.2: -95 °C / Inert atmosphere 3.1: trifluoroacetic acid / dichloromethane / 0 °C / Inert atmosphere 4.1: [Ru(bpyrz)3](PF6)2*2H2O / methanol; acetonitrile / 18 h / 20 °C / Air; Visible light; Irradiation View Scheme
参考文献
Zhu, Mingzhao; Zheng, Nan
Synthesis, 2011 , # 14 art. no. C01611SS, p. 2223 - 2236
反应条件
1: With triethylamine in dichloromethane 2: With trifluoroacetic acid in dichloromethane T=0°C; 0.5 h; 3: With sodium hydroxide T=0°C;
参考文献
Chen, Shoujun; Sun, Lijun; Koya, Keizo; Tatsuta, Noriaki; Xia, Zhiqiang; Korbut, Timothy; Du, Zhenjian; Wu, Jim; Liang, Guiqing; Jiang, Jun; Ono, Mitsunori; Zhou, Dan; Sonderfan, Andrew
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 18 p. 5070 - 5076
反应条件
1: N1-Boc-N2-phenyl-hydrazine With n-butyllithium in tetrahydrofuran; hexane T=-78 - -45°C; 0.25 h; Inert atmosphere; 2: 2,2'-bis(bromomethyl)-1,1'-biphenyl in tetrahydrofuran; hexane T=-45°C; 1 h; Inert atmosphere;
参考文献
Organometallics, , vol. 33, # 1 p. 188 - 193
反应条件
1: N1-Boc-N2-phenyl-hydrazine With n-butyllithium in tetrahydrofuran; hexane T=-78 - -45°C; 0.25 h; Inert atmosphere; 2: 2,2'-bis(bromomethyl)-1,1'-biphenyl in tetrahydrofuran; hexane T=-45°C; 24 h; Inert atmosphere;
参考文献
Organometallics, , vol. 33, # 1 p. 188 - 193
反应条件
1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere 1.2: 1 h / 0 °C / Inert atmosphere 2.1: trifluoroacetic acid / dichloromethane / 0 °C / Inert atmosphere View Scheme
参考文献
Zhu, Mingzhao; Zheng, Nan
Synthesis, 2011 , # 14 art. no. C01611SS, p. 2223 - 2236
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile T=20°C; Acylation; 3 h;
参考文献
Loog; Maeorg; Ragnarsson
Synthesis, 2000 , # 11 p. 1591 - 1597
反应条件
1: 75 percent / K2CO3 / dimethylformamide 2: 92 percent / TFA / CH2Cl2 / 1 h View Scheme
参考文献
Di Fabio, Romano; Araldi, Gianluca; Baraldi, Davide; Cugola, Alfredo; Donati, Daniele; Gastaldi, Paola; Giacobbe, Simone A; Micheli, Fabrizio; Pentassuglia, Giorgio
Farmaco, 2001 , vol. 56, # 10 p. 791 - 798
参考文献
Kumar, K. Shiva; Iqbal, Javed; Pal, Manojit
Tetrahedron Letters, 2009 , vol. 50, # 46 p. 6244 - 6246
反应条件
in toluene
T=20°C; 72 h;
参考文献
Armstrong, Alan; Jones, Lyn H.; Knight, Jamie D.; Kelsey, Richard D.
Organic Letters, 2005 , vol. 7, # 4 p. 713 - 716
反应条件
1: (CF3CO)2O / pyridine
2: CH2Cl2
View Scheme
参考文献
Carpino,L.A.
Journal of the American Chemical Society, 1960 , vol. 82, p. 2725 - 2727
