2,4-二甲基-1-碘苯合成路线 （共 38 条）
反应条件
in neat (no solvent)
charging of NMR tube with Pd(P(t-Bu)3)2 and Me2C6H3I in a glovebox; heating at 70°C (J. Am. Chem. Soc. 2002, 124, 9346);
参考文献
Stambuli, James P.; Incarvito, Christopher D.; Buehl, Michael; Hartwig, John F.
Journal of the American Chemical Society, 2004 , vol. 126, # 4 p. 1184 - 1194
反应条件
in tetrahydrofuran
25°C, Pd concn. below 0.1 M in THF; soln. concd.; ppt. sepd.;
参考文献
Stambuli, James P.; Buehl, Michael; Hartwig, John F.
Journal of the American Chemical Society, 2002 , vol. 124, # 32 p. 9346 - 9347
反应条件
triethylamine tris(hydrogen fluoride) in N,N-dimethyl-formamide
T=23 - 50°C; 42 h; GloveboxSealed tube;
参考文献
Lishchynskyi, Anton; Novikov, Maxim A.; Martin, Eddy; Escudero-Adan, Eduardo C.; Novak, Petr; Grushin, Vladimir V.
Journal of Organic Chemistry, 2013 , vol. 78, # 22 p. 11126 - 11146
反应条件
copper(l) iodide; 3,4,7,8-tetra-methyl-1,10-phenanthroline; caesium carbonate in toluene
T=110°C; 16 h;
参考文献
Polaske, Nathan W.; Szalai, Michael L.; Shanahan, Charles S.; McGrath, Dominic V.
Organic Letters, 2010 , vol. 12, # 21 p. 4944 - 4947
反应条件
1: With 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate in toluene
T=100°C; 1 h; Inert atmosphere;
2: With hydrogen bromide in toluene
T=60°C; Time;
参考文献
H. LUNDBECK A/S; CHRISTENSEN, Kim, Lasse
Patent: WO2013/102573 A1, 2013 ;
Location in patent: Page/Page column 13; 14 ;
反应条件
N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in water; isopropyl alcohol
T=100°C; Suzuki coupling; 0.166667 h; microwave irradiation;
参考文献
Kabalka, George W.; Al-Masum, Mohammad
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6329 - 6331
反应条件
1: With sulfuric acid
T=50 - 55°C;
2: With sodium periodate
T=50 - 55°C; 3 h;
3: With potassium bromide in water
参考文献
Niu, Hong-Ying; Xia, Chao; Qu, Gui-Rong; Zhang, Qian; Jiang, Yi; Mao, Run-Ze; Li, De-Yang; Guo, Hai-Ming
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 14 p. 5039 - 5042
参考文献
Mascarelli; Longo
Gazzetta Chimica Italiana, 1941 , vol. 71, p. 389,392
反应条件
palladium diacetate in acetonitrile
T=160°C; 0.75 h; Microwave irradiationsealed vessel;
参考文献
IDENIX PHARMACEUTICALS, INC.; DOUSSON, Cyril; SURLERAUX, Dominique; PAPARIN, Jean-laurent; PIERRA, Claire; GRIFFON, Jean-francois; LEROY, Frederic; DUKHAN, David
Patent: WO2010/101967 A2, 2010 ;
Location in patent: Page/Page column 145 ;
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-di(diphenylphosphino)-butane in dimethyl sulfoxide
T=30 - 80°C; 9 h; DarknessAerobic condition;
参考文献
Kim, Yong; Park, Ahbyeol; Park, Kyungho; Lee, Sunwoo
Tetrahedron Letters, 2011 , vol. 52, # 15 p. 1766 - 1769
