2-氨基-3,5二氯吡啶合成路线 （共 25 条）
反应条件
nitrosyl sulfuric acid versetzt das Reaktionsgemisch mit Wasser und erhitzt kurze Zeit zum Sieden;
参考文献
Tschitschibabin; Jegorow
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1928 , vol. 60, p. 689
Chem. Zentralbl., 1928 , vol. 99, # II p. 1671
反应条件
potassium hydroxide in diethylene glycol dimethyl ether; ethylene glycol; ethyl acetate
参考文献
Ciba-Geigy Corporation
Patent: US4033975 A1, 1977 ;
反应条件
ammonium hydrogen difluoride; hydrogen fluoride; sodium nitrite T=21 - 64°C; 4 h;
参考文献
Boudakian, Max M.
Journal of Fluorine Chemistry, 1981 , vol. 18, p. 497 - 506
反应条件
dipotassium peroxodisulfate; sulfuric acid T=20°C;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2006/47504 A1, 2006 ;
Location in patent: Page/Page column 115-116 ;
WO 2006/047504 A1
参考文献
Pfizer Inc.
Patent: US4510148 A1, 1985 ;
反应条件
1: in ethanol 2 h; Heating / reflux; 2: With sodium hydrogencarbonate in ethanol 15 h; Heating / reflux;
参考文献
AUSTRALIAN NUCLEAR SCIENCE and TECHNOLOGY ORGANISATION
Patent: WO2008/22396 A1, 2008 ;
Location in patent: Page/Page column 44 ;
反应条件
sodium nitrite in hydrogenchloride; hexane; water
参考文献
Tschitschibabin; Jegorow
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1928 , vol. 60, p. 689
Chem. Zentralbl., 1928 , vol. 99, # II p. 1671
参考文献
Chem. Fabr. Schering
Patent: DE400191 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 14, p. 533
反应条件
n-butyllithium in 1,4-dioxane; hexane 2 h; Heating;
参考文献
Couture, Axel; Huguerre, Eric; Grandclaudon, Pierre
Synthetic Communications, 1989 , vol. 19, # 3and4 p. 713 - 719
反应条件
sodium hydride in N,N-dimethyl-formamide
12 h; Ambient temperature;
参考文献
Ferranti; Garuti; Giovanninetti; Borgatti; Bartoletti
Archiv der Pharmazie, 1985 , vol. 318, # 1 p. 78 - 84
