N-甲基-3-苯基-3-羟基丙胺合成路线 （共 25 条）
反应条件
1: With sodium tetrahydroborate in acetic acid T=5 - 10°C; 3.5 h; 2: With sodium hydroxide pH=12;
参考文献
Board of Regents, The University of Texas System
Patent: US2004/102651 A1, 2004 ;
Location in patent: Page 4 ;
反应条件
hydrogen; 5 PdCl2 on carbon in water; ethyl acetate T=55 - 57°C; P=2206.72 - 2574.5 Torr; 1 h;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2006/37055 A1, 2006 ;
Location in patent: Page/Page column 21-22 ;
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate P=3750.3 Torr; 144 h;
参考文献
Kellogg, Richard M.; Nieuwenhuijzen, Jose W.; Pouwer; Vries, Ton R.; Broxterman, Quirinus B.; Grimbergen, Reinier F.P.; Kaptein, Bernard; La Crois, Rene M.; De Wever, Ellen; Zwaagstra, Karen; Van Der Laan, Alexander C.
Synthesis, 2003 , # 10 p. 1626 - 1638
参考文献
Albemarle Corporation
Patent: US5892117 A1, 1999 ;
反应条件
in water; acetonitrile T=140°C; 0.166667 h;
参考文献
Ahmed-Omer, Batoul; Sanderson, Adam J.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 10 p. 3854 - 3862
反应条件
sodium tetrahydroborate in methanol T=20°C; 1 h;
参考文献
Liu, Duan; Gao, Wenzhong; Wang, Chunjiang; Zhang, Xumu
Angewandte Chemie - International Edition, 2005 , vol. 44, # 11 p. 1687 - 1689
反应条件
in tetrahydrofuran; water T=80°C; 0.166667 h;
参考文献
Ahmed-Omer, Batoul; Sanderson, Adam J.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 10 p. 3854 - 3862
反应条件
1: hydrogen chloride / methanol / 1.5 h / 83 - 88 °C 2: H2 / Pd-C / ethyl acetate View Scheme
参考文献
Liu, Duan; Gao, Wenzhong; Wang, Chunjiang; Zhang, Xumu
Angewandte Chemie - International Edition, 2005 , vol. 44, # 11 p. 1687 - 1689
反应条件
1: borane-THF / tetrahydrofuran / 0.08 h / 20 °C 2: sodium iodide / acetone / 16 h / Reflux 3: tetrahydrofuran; water / 0.17 h / 80 °C View Scheme
参考文献
Hadrich, Dirk; Berthold, Frank; Steckhan, Eberhard; Boenisch, Heinz
Journal of Medicinal Chemistry, 1999 , vol. 42, # 16 p. 3101 - 3108
反应条件
1: sodium iodide / acetone / 16 h / Reflux 2: tetrahydrofuran; water / 0.17 h / 80 °C View Scheme
参考文献
Velingkar; Dandekar
Chinese Journal of Chemistry, 2011 , vol. 29, # 3 p. 504 - 510
